63498-15-7

Usage

Chemical Properties

white powder

InChI:InChI=1/C8H4Cl2F3NO/c9-5-2-3(7(10)15)1-4(6(5)14)8(11,12)13/h1-2H,14H2

Upstream product

• 400-76-0 4-amino-3-(trifluoromethyl)benzoic acid 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 175277-96-0 N-(4-cyano-2-(trifluoromethyl)phenyl)acetamide 
• 97760-98-0 N-(4-iodo-2-(trifluoromethyl)phenyl)acetamide 
• 97760-97-9 4-iodo-2-(trifluoromethyl)aniline 
• 95656-52-3 4-amino-3-chloro-5-(trifluoromethyl)benzoic acid 

Downstream Products

• 63497-89-2 4-Amino-N-benzyl-3-chloro-5-trifluoromethyl-benzoic acid amide 
• 63497-87-0 4-Amino-3-chloro-N-cyclopropyl-5-trifluoromethyl-benzoic acid amide 
• 63497-65-4 4-Amino-3-chloro-N-(2-piperidino-ethyl)-5-trifluoromethyl-benzoic acid amide 
• 63497-66-5 4-Amino-3-chloro-N-(2-pyrrolidino-ethyl)-5-trifluoromethyl-benzoic acid amide 
• 63497-63-2 4-amino-3-chloro-N-(2-morpholin-4-yl-ethyl)-5-trifluoromethyl-benzamide 
• 63497-86-9 4-Amino-N-tert.butyl-3-chloro-5-trifluoromethyl-benzoic acid amide 
• 848130-79-0 2-chloro-4-oxiran-2-yl-6-(trifluoromethyl)aniline 
• 97760-87-7 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-bromoethanone 
• 63497-88-1 4-Amino-N-(n-butyl)-3-chloro-5-trifluoromethyl-benzoic acid amide 
• 97776-04-0 diethyl 2-(4-amino-3-chloro-5-trifluoromethyl-benzoyl)-malonate 
• 97760-76-4 4'-amino-3'-chloro-5'-trifluoromethyl-acetophenone 

Relevant academic research and scientific papers

Synthesis of deuterium-labelled trantinterol

Trantinterol, a selective β2-adrenoceptor agonist, is currently in Phase II clinical trials for the treatment of asthma and bronchitis. The synthesis of deuterium-labelled trantinterol is described. The labelled trantinterol is used as an inter

NOVEL PHENYLETHANOLAMINE COMPOUNDS HAVING BETA2-ACCEPTOR EXCITATORY FUNCTION AND THEIR PREPARATION METHOD

The invention provides compounds of formula ( I ) and pharmaceutically acceptable salts thereof, wherein R1 is H, chlorine, or bromine; R2 is electron attractive groups selected from the group consisting of CF3, CN, fluori

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.