1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE

Base Information

• Chemical Name: 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE
• CAS No.: 99010-24-9
• Molecular Formula: C14H15N3
• Molecular Weight: 225.293
• Hs Code.: 2933990090
• Mol file: 99010-24-9.mol

Synonyms:1H-IMIDAZO[4,5-C]QUINOLINE, 1-(2-METHYLPROPYL)-;1-ISOBUTYL-1H-IMIDAZO[4,5-C]QUINOLINE;1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE;Imiquimod Related Compound A (25 mg) (1-Isobutyl-1H-imidazo[4,5-c]quinoline);IMiquiMod Related CoMpound A;DesaMino IMiquiMod

Chemical Property of 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE

Chemical Property:

• Vapor Pressure: 1.08E-06mmHg at 25°C
• Melting Point: 92-95℃
• Boiling Point: 402.6°C at 760 mmHg
• PKA: 5.34±0.30(Predicted)
• Flash Point: 197.3°C
• PSA: 30.71000
• Density: 1.17g/cm³
• LogP: 3.24050
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

DesaminoImiquimod ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Desamino Imiquimod is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.

Technology Process of 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE

There total 11 articles about 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-Amino-4-(2-methylpropylamino)-quinoline (99010-09-0) + formic acid (64-18-6) → 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (99010-24-9)

Guidance literature:

3-Amino-4-(2-methylpropylamino)-quinoline; formic acid; at 110 - 115 ℃; for 8 - 10h;

With sodium hydroxide; In water; at 20 ℃; pH=10 - 11;

Reference yield: 15.0%

3-amino-quinolin-4-ol; hydrochloride (129377-66-8) + isobutylamine (78-81-9) → 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (99010-24-9)

Guidance literature:

3-amino-quinolin-4-ol; hydrochloride; N,N-dimethyl-formamide; With trichlorophosphate; In acetonitrile; at 20 ℃; for 21h;

isobutylamine; In acetonitrile; at 120 ℃; for 3h; Product distribution / selectivity;

Reference yield:

3-Amino-4-(2-methylpropylamino)-quinoline (99010-09-0) + orthoformic acid triethyl ester (122-51-0) → 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (99010-24-9)

Guidance literature:

With formic acid; In toluene; at 102 - 110 ℃; d;

upstream raw materials:

3-Amino-4-(2-methylpropylamino)-quinoline

diethoxymethyl acetate

N-(2-methylpropyl)-3-nitro-4-quinolinamine

quinolin-4-ol

Downstream raw materials:

α-butyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2-methanol

2-(2-methoxyethyl)-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline

α-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2-methanol

1-(2-methylpropyl)-α-phenyl-1H-imidazo[4,5-c]quinoline-2-methanol

Refernces

• 1、 -. "METHOD FOR 1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF". Page/Page column 90-91. . Retrieved 2008/06/13.
• 2、 -. "A PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE 4-AMINO-1-ISOBUTYL-1H-IMIDAZO[4,5-C]-QUINOLINE (IMIQUIMOD)". Page/Page column 7; 11. . Retrieved 2008/06/13.