Thieno[2,3-b]pyridine, 6-phenyl-

Base Information

• Chemical Name: Thieno[2,3-b]pyridine, 6-phenyl-
• CAS No.: 100037-80-7
• Molecular Formula: C13H9NS
• Molecular Weight: 211.287
• Mol file: 100037-80-7.mol

Synonyms:

Chemical Property of Thieno[2,3-b]pyridine, 6-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thieno[2,3-b]pyridine, 6-phenyl-

There total 14 articles about Thieno[2,3-b]pyridine, 6-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(thiophen-2-yl)-2-phenyl-4-trimethylsilyl-1-azabut-1-en-3-yne → 6-phenyl-thieno[2,3-b]pyridine (100037-80-7)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; ammonium hexafluorophosphate; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); In toluene; at 105 ℃; for 19h;

DOI:10.1021/ja060626a

Reference yield: 82.0%

thiophen-2-ylamine (616-46-6) + 3-phenyl-propenal (104-55-2) → 6-phenyl-thieno[2,3-b]pyridine (100037-80-7)

Guidance literature:

In water; acetic acid; for 0.05 - 0.0583333h; Microwave irradiation;

Reference yield:

2-nitro-3-thiophenecarbaldehyde (41057-04-9) → 6-phenyl-thieno[2,3-b]pyridine (100037-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; ethanolic NaOH-solution

2: SnCl₂; aq.-ethanolic HCl / anschliessend Behandeln mit wss. KOH

With hydrogenchloride; sodium hydroxide; diethyl ether; tin(ll) chloride;

DOI:10.1021/ja01571a048

upstream raw materials:

3t-(2-nitro-[3]thienyl)-1-phenyl-propenone

6-phenyl-2,3-dihydrothieno-<2,3-b>pyridine 1-oxide

hydrogenchloride

N-(thiophen-2-yl)benzamide

Refernces

• 1、 Kidwai,Priya,Poddar. "Ecofriendly synthesis of thieno[2,3-b]pyridines derivativies". experimental part. p. 270 - 273. Retrieved 2010/11/02.
• 2、 Taylor, Edward C.,Macor, John E.. "Intramolecular Diels-Alder Reactions of 1,2,4-Triazines. A Facile Synthesis of Thienopyridines and 3,4-Dihydro-2H-thiopyranopyridines". . p. 4280 - 4287. Retrieved 2007/10/02.