Technology Process of (E)-3-(4-tert-butylphenyl)-N-[3-fluoro-4-(methylsulfonamido)benzyl]-3-phenylacrylamide
There total 6 articles about (E)-3-(4-tert-butylphenyl)-N-[3-fluoro-4-(methylsulfonamido)benzyl]-3-phenylacrylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; diethyl ether / 2 h / -78 °C
2.1: dipyridinium dichromate / dichloromethane / 12 h / 20 °C / Molecular sieve
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 12 h / 0 - 20 °C / Inert atmosphere
4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C
5.1: triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / tetrahydrofuran / 14 h
With
4-methyl-morpholine; dipyridinium dichromate; lithium hydroxide monohydrate; sodium hydride; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; mineral oil;
DOI:10.1007/s12272-013-0228-x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 12 h / 0 - 20 °C / Inert atmosphere
2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C
3.1: triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / tetrahydrofuran / 14 h
With
4-methyl-morpholine; lithium hydroxide monohydrate; sodium hydride; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
tetrahydrofuran; water; mineral oil;
DOI:10.1007/s12272-013-0228-x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dipyridinium dichromate / dichloromethane / 12 h / 20 °C / Molecular sieve
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C
4.1: triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / tetrahydrofuran / 14 h
With
4-methyl-morpholine; dipyridinium dichromate; lithium hydroxide monohydrate; sodium hydride; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
tetrahydrofuran; dichloromethane; water; mineral oil;
DOI:10.1007/s12272-013-0228-x
