4-Benzyloxy-2-cyanopyridine

Base Information

• Chemical Name: 4-Benzyloxy-2-cyanopyridine
• CAS No.: 100382-00-1
• Molecular Formula: C13H10N2O
• Molecular Weight: 210.235
• Hs Code.: 2933399090
• Mol file: 100382-00-1.mol

Synonyms:4-phenylmethoxypyridine-2-carbonitrile;

Chemical Property of 4-Benzyloxy-2-cyanopyridine

Chemical Property:

• PSA: 45.91000
• LogP: 2.53228
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(Benzyloxy)picolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Benzyloxy-2-cyanopyridine

There total 4 articles about 4-Benzyloxy-2-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

4-benzyloxypyridine-N-oxide (2683-66-1) + trimethylsilyl cyanide (7677-24-9) → 4-benzyloxypyridine-2-carbonitrile (100382-00-1)

Guidance literature:

With N,N-Dimethylcarbamoyl chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

4-chloro-pyridine-2-carbonitrile (19235-89-3) + benzyl alcohol (100-51-6,185532-71-2) → 4-benzyloxypyridine-2-carbonitrile (100382-00-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 25 ℃; for 1h;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 4-benzyloxypyridine-2-carbonitrile (100382-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

1.2: 100 °C

2.1: N,N-Dimethylcarbamoyl chloride / dichloromethane / 0 - 20 °C

With sodium hydride; N,N-Dimethylcarbamoyl chloride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

4-benzyloxypyridine-N-oxide

trimethylsilyl cyanide

benzyl alcohol

4-nitraminopyridine N-oxide

Downstream raw materials:

C₁₉H₁₇NO₃

4-(benzyloxy)picolinic acid

4-(benzyloxy)pyridine-2-carbaldehyde

(4-benzyloxy-2-pyridyl)methanamine

Refernces

• 1、 -. "FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME". Paragraph 00182. . Retrieved 2018/03/06.