Technology Process of (4R,6R)-4-(2-Benzyloxy-ethyl)-2,2-dimethyl-6-vinyl-[1,3]dioxane
There total 9 articles about (4R,6R)-4-(2-Benzyloxy-ethyl)-2,2-dimethyl-6-vinyl-[1,3]dioxane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) nBuLi, 2) BF3*Et2O / 1) THF, 2) THF
2: H2 / Lindlar catalyst / ethanol / 760 Torr / Ambient temperature
3: tBuOOH, VO(acac)2 / toluene / -15 deg C to rt
4: nBu4NF / tetrahydrofuran / 0.5 h / Ambient temperature
5: p-TsOH
With
tert.-butylhydroperoxide; n-butyllithium; bis(acetylacetonate)oxovanadium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid;
Lindlar's catalyst;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1016/S0040-4039(00)92213-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / Lindlar catalyst / ethanol / 760 Torr / Ambient temperature
2: tBuOOH, VO(acac)2 / toluene / -15 deg C to rt
3: nBu4NF / tetrahydrofuran / 0.5 h / Ambient temperature
4: p-TsOH
With
tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid;
Lindlar's catalyst;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1016/S0040-4039(00)92213-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / H2 / Pd/C, poisoned with pyridine / ethyl acetate
2: TBHP / VO(acac)2 / CH2Cl2; 1,2-dichloro-ethane / 0 degC, 8h, then room temperature, 24h
3: pTsOH
With
tert.-butylhydroperoxide; hydrogen;
palladium on activated charcoal; bis(acetylacetonate)oxovanadium; poisoned with pyridine; toluene-4-sulfonic acid;
In
dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)95736-8
