Z-Dl-Ala-Gly-OH

Base Information

• Chemical Name: Z-Dl-Ala-Gly-OH
• CAS No.: 3235-17-4
• Molecular Formula: C₁₃H₁₆N₂O₅
• Molecular Weight: 280.28
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID00954135
• Mol file: 3235-17-4.mol

Synonyms:Z-Dl-Ala-Gly-OH;2503-31-3;n-[(benzyloxy)carbonyl]alanylglycine;EpothiloneD;EINECS 221-791-0;SCHEMBL9574094;DTXSID00954135;((Benzyloxy)carbonyl)alanylglycine;CS-0450056;FT-0634738;N-(N-((Phenylmethoxy)carbonyl)-L-alanyl)glycine;2-(2-(benzyloxycarbonylamino)propanamido)acetic acid;J-015782;2-(2-{[(benzyloxy)carbonyl]amino}propanamido)acetic acid;2-(2-phenylmethoxycarbonylamino-propanoylamino)-acetic acid;[(2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]acetic acid;N-(2-{[(Benzyloxy)(hydroxy)methylidene]amino}-1-hydroxypropylidene)glycine

Chemical Property of Z-Dl-Ala-Gly-OH

Chemical Property:

• Vapor Pressure: 3.18E-14mmHg at 25°C
• Melting Point: 104 °C
• Refractive Index: 1.55
• Boiling Point: 578.5 °C at 760 mmHg
• PKA: 3.42±0.10(Predicted)
• Flash Point: 303.7 °C
• PSA: 104.73000
• Density: 1.285 g/cm³
• LogP: 1.28390
• Storage Temp.: Store at 0°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 280.10592162
• Heavy Atom Count: 20
• Complexity: 353

Purity/Quality:

98%Min ^*data from raw suppliers

Z-Ala-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)NCC(=O)O)NC(=O)OCC1=CC=CC=C1

Technology Process of Z-Dl-Ala-Gly-OH

There total 19 articles about Z-Dl-Ala-Gly-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N,O-bis(trimethylsilyl)glycine (7364-42-3) + N-Cbz-Ala (1142-20-7) → N-benzyloxycarbonyl-L-alanylglycine (2503-31-3,3235-17-4,34286-66-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/jo2024703

Reference yield: 89.0%

3-(N-benzyloxycarbonyl-L-alanyl)-1,3-thiazolidine-2-thione (76413-56-4) + glycine (56-40-6,18875-39-3,25718-94-9) → N-benzyloxycarbonyl-L-alanylglycine (2503-31-3,3235-17-4,34286-66-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; for 0.0166667h; Ambient temperature; other 3-acyl-1,3-thiazolidine-2-thione;

DOI:10.1246/cl.1981.463

Reference yield: 80.0%

Z-L-Ala-Gly-OMe (4840-29-3) → N-benzyloxycarbonyl-L-alanylglycine (2503-31-3,3235-17-4,34286-66-3)

Guidance literature:

With sodium hydroxide; In water; acetone; at 20 ℃; for 0.75h;

DOI:10.1021/acs.jmedchem.9b00823

upstream raw materials:

ethyl N-(benzyloxycarbonyl)-L-alanylglycinate

Z-L-Ala-Gly-OMe

Benzyloxycarbonyl-L-alaninphenylthiolester

glycine

Downstream raw materials:

S-benzyl-N-{N-[N-(N-benzyloxycarbonyl-L-alanyl)-glycyl]-L-valyl}-L-cysteine benzyl ester

alanylglycine

Z-Ala-Gly-Boc Hydrazid

C₅₂H₆₄N₆O₁₅

Refernces

• 1、 Vishwanatha,Narendra,Chattopadhyay, Basab,Mukherjee, Monika,Sureshbabu, Vommina V.. "Synthesis of selenoxo peptides and oligoselenoxo peptides employing LiAlHSeH". experimental part. p. 2689 - 2702. Retrieved 2012/06/01.
• 2、 Link, Peter,Voelter, Wolfgang. "Total Synthesis of Thymosin β4, 3. Conventional Synthesis of the Fragment of Thymosin β4". . p. 1000 - 1008. Retrieved 2007/10/02.