2-(2,3-DIFLUOROPHENYL)-5-(METHOXYCARBONYL)-1-METHYL-3-PYRROLIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 2-(2,3-DIFLUOROPHENYL)-5-(METHOXYCARBONYL)-1-METHYL-3-PYRROLIDINECARBOXYLIC ACID
• CAS No.: 1096442-76-0
• Molecular Formula: C₁₄H₁₅F₂NO₄
• Molecular Weight: 299.274
• Hs Code.: 2933998090
• Mol file: 1096442-76-0.mol

Synonyms:

Chemical Property of 2-(2,3-DIFLUOROPHENYL)-5-(METHOXYCARBONYL)-1-METHYL-3-PYRROLIDINECARBOXYLIC ACID

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(2,3-Difluorophenyl)-5-(methoxycarbonyl)-1-methyl-3-pyrrolidinecarboxylic acid >95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-(2,3-DIFLUOROPHENYL)-5-(METHOXYCARBONYL)-1-METHYL-3-PYRROLIDINECARBOXYLIC ACID

There total 3 articles about 2-(2,3-DIFLUOROPHENYL)-5-(METHOXYCARBONYL)-1-METHYL-3-PYRROLIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(+/-)-(2S,4S,5R)-5-(2,3-difluorophenyl)pyrrolidine-2,4-dicarboxylic acid 4-tert-butyl ester 2-methyl ester + formic acid (64-18-6) → (+/-)-(2S,4S,5R)-5-(2,3-difluorophenyl)-1-methylpyrrolidine-2,4-dicarboxylic acid 2-methyl ester (1096442-76-0)

Guidance literature:

With formaldehyd; at 100 ℃; for 0.666667h;

DOI:10.1002/jhet.5570430608

Reference yield:

[(2,3-difluoro-benzylidene)-amino]-acetic acid methyl ester → (+/-)-(2S,4S,5R)-5-(2,3-difluorophenyl)-1-methylpyrrolidine-2,4-dicarboxylic acid 2-methyl ester (1096442-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / lithium bromide; Et₃N / tetrahydrofuran / 24 h / 20 °C

2: 40 percent / aq. formaldehyde / 0.67 h / 100 °C

With formaldehyd; triethylamine; lithium bromide; In tetrahydrofuran;

DOI:10.1002/jhet.5570430608

Reference yield:

2,3-difluorobenzaldehyde (2646-91-5) → (+/-)-(2S,4S,5R)-5-(2,3-difluorophenyl)-1-methylpyrrolidine-2,4-dicarboxylic acid 2-methyl ester (1096442-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1: MgSO₄; NEt₃ / CH₂Cl₂ / 20 °C

2: 92 percent / lithium bromide; Et₃N / tetrahydrofuran / 24 h / 20 °C

3: 40 percent / aq. formaldehyde / 0.67 h / 100 °C

With formaldehyd; magnesium sulfate; triethylamine; lithium bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jhet.5570430608

upstream raw materials:

formic acid

2,3-difluorobenzaldehyde

Refernces