4-(4-chloro-phenyl)-heptanedioic acid diethyl ester

Base Information

• Chemical Name: 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester
• CAS No.: 101598-25-8
• Molecular Formula: C₁₇H₂₃ClO₄
• Molecular Weight: 326.82
• Mol file: 101598-25-8.mol

Synonyms:

Chemical Property of 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester

There total 6 articles about 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-chlorophenyl)pentane-1,5-dioic acid (35271-74-0) → 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester (101598-25-8)

Guidance literature:

Multi-step reaction with 5 steps

2: LiAlH₄; diethyl ether

3: hydrogen bromide / 120 - 130 °C

5: H₂SO₄

With lithium aluminium tetrahydride; diethyl ether; sulfuric acid; hydrogen bromide;

DOI:10.1021/ja01530a050

Reference yield:

1,5-dibromo-3-(4-chloro-phenyl)-pentane (100126-12-3) → 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester (101598-25-8)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂SO₄

With sulfuric acid;

DOI:10.1021/ja01530a050

Reference yield:

3-(4-chlorophenyl)pentane-1,5-diol (103502-34-7) → 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester (101598-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide / 120 - 130 °C

3: H₂SO₄

With sulfuric acid; hydrogen bromide;

DOI:10.1021/ja01530a050

upstream raw materials:

ethanol

4-(4-chloro-phenyl)-heptanedinitrile

3-(4-chlorophenyl)pentane-1,5-dioic acid

1,5-dibromo-3-(4-chloro-phenyl)-pentane

Downstream raw materials:

5-(4-chloro-phenyl)-nonanedinitrile

5-(4-chloro-phenyl)-cyclooctanone

1,7-dibromo-4-(4-chloro-phenyl)-heptane

4-(4-chlorophenyl)cyclohexan-1-one