5-bromo-7-(trifluoromethyl)-1H-indazole

Base Information

• Chemical Name: 5-bromo-7-(trifluoromethyl)-1H-indazole
• CAS No.: 1374258-43-1
• Molecular Formula: C₈H₄BrF₃N₂
• Molecular Weight: 265.032
• Hs Code.: 2933998090
• Mol file: 1374258-43-1.mol

Synonyms:

Chemical Property of 5-bromo-7-(trifluoromethyl)-1H-indazole

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

5-bromo-7-(trifluoromethyl)-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-7-(trifluoromethyl)-1H-indazole

There total 2 articles about 5-bromo-7-(trifluoromethyl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

4-bromo-2-methyl-6-(trifluoromethyl)aniline (864539-96-8) → 5-bromo-7-(trifluoromethyl)-1H-indazole (1374258-43-1)

Guidance literature:

4-bromo-2-methyl-6-(trifluoromethyl)aniline; With potassium acetate; acetic anhydride; In chloroform; at 0 - 20 ℃; for 1h;

With tert.-butylnitrite; In chloroform; at 60 ℃;

Reference yield:

2-methyl-6-(trifluoromethyl)aniline (88301-98-8) → 5-bromo-7-(trifluoromethyl)-1H-indazole (1374258-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 - 20 °C

2.1: potassium acetate; acetic anhydride / chloroform / 1 h / 0 - 20 °C

2.2: 60 °C

With N-Bromosuccinimide; potassium acetate; acetic anhydride; In chloroform; acetonitrile;

Reference yield: 69.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 5-bromo-7-(trifluoromethyl)-1H-indazole (1374258-43-1) → methyl 7-(trifluoromethyl)-1H-indazole-5-carboxylate (1374258-44-2)

Guidance literature:

With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; at 20 - 70 ℃; for 53h; Sealed tube;

upstream raw materials:

2-methyl-6-(trifluoromethyl)aniline

4-bromo-2-methyl-6-(trifluoromethyl)aniline

Downstream raw materials:

methyl 7-(trifluoromethyl)-1H-indazole-5-carboxylate

Refernces

• 1、 -. "N1/N2-Lactam Acetyl-CoA carboxylase inhibitors". . . Retrieved 2012/05/07.