2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE

Base Information

Chemical Name:2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE
CAS No.:10189-45-4
Molecular Formula:C12H9ClN2O2
Molecular Weight:248.669
Hs Code.:
Mol file:10189-45-4.mol

Synonyms:2-chloro-N-(2-hydroxy-phenyl)-nicotinamide;2-chloro-N-(2-hydroxyphenyl)nicotinic acid amide;2-Chlor-nicotinsaeure-(2-hydroxyanilid);N-(2-hydroxyphenyl)-2-chloro-3-pyridinecarboxamide;

Suppliers and Price of 2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE 95.00%
5MG
$ 633.99

American Custom Chemicals Corporation
2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE 95.00%
10MG
$ 631.85

American Custom Chemicals Corporation
2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE 95.00%
1MG
$ 597.89

Total 6 raw suppliers

Chemical Property of 2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE

Chemical Property:

Melting Point:162 °C
Boiling Point:339.9±37.0 °C(Predicted)
PKA:8.76±0.35(Predicted)
PSA：62.22000
Density:1.446±0.06 g/cm3(Predicted)
LogP:2.76590

Purity/Quality:

97% ^*data from raw suppliers

2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE

There total 7 articles about 2-CHLORO-N-(2-HYDROXY-PHENYL)-NICOTINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 49609-84-9
2-Chloronicotinoyl chloride

: 95-55-6
2-amino-phenol

: 10189-45-4
2-chloro-N-(2-hydroxyphenyl)nicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 4 ℃; for 1h;

Reference yield:

: 95-55-6
2-amino-phenol

: 121495-79-2
2-chloropyridine-3-carbonyl chloride hydrochloride

: 10189-45-4
2-chloro-N-(2-hydroxyphenyl)nicotinamide

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 10189-45-4
2-chloro-N-(2-hydroxyphenyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: (i-Pr)2NEt / ethyl acetate / 2 h / 0 °C

2: NaOH / dimethylformamide / 5 h / 120 °C

3: NaH / dimethylformamide / Ambient temperature

With sodium hydroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a027