4-(6-Methoxybenzo[d]thiazol-2-yl)-N,N-dimethylaniline

Base Information

• Chemical Name: 4-(6-Methoxybenzo[d]thiazol-2-yl)-N,N-dimethylaniline
• CAS No.: 10205-71-7
• Molecular Formula: C16H16N2OS
• Molecular Weight: 284.382
• DSSTox Substance ID: DTXSID00456326
• Nikkaji Number: J2.139.198K
• Wikidata: Q82278723
• Pharos Ligand ID: 7JF7SMM1BSYY
• ChEMBL ID: CHEMBL328430
• Mol file: 10205-71-7.mol

Synonyms:4-(6-Methoxybenzo[d]thiazol-2-yl)-N,N-dimethylaniline;10205-71-7;CHEMBL328430;4-(6-METHOXY-1,3-BENZOTHIAZOL-2-YL)-N,N-DIMETHYLANILINE;SCHEMBL2119782;DTXSID00456326;Benzenamine, 4-(6-methoxy-2-benzothiazolyl)-N,N-dimethyl-;BDBM50129784;MFCD22570301;NCGC00167607-01;AS-70313;PD119811;CS-0160965;FT-0688501;C71099;A846466;2-[4-(Dimethylamino)phenyl]-6-methoxybenzothiazole;2-(4'-(dimethylamino)phenyl)-6-methoxybenzothiazole;[4-(6-Methoxy-benzothiazol-2-yl)-phenyl]-dimethyl-amine

Chemical Property of 4-(6-Methoxybenzo[d]thiazol-2-yl)-N,N-dimethylaniline

Chemical Property:

• Melting Point: 182 °C
• Boiling Point: 447.873 °C at 760 mmHg
• Flash Point: 224.666 °C
• Density: 1.218 g/cm³
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 284.09833431
• Heavy Atom Count: 20
• Complexity: 318

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)C2=NC3=C(S2)C=C(C=C3)OC

Technology Process of 4-(6-Methoxybenzo[d]thiazol-2-yl)-N,N-dimethylaniline

There total 14 articles about 4-(6-Methoxybenzo[d]thiazol-2-yl)-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-dimethylamino-N-(4'-methoxyphenyl)-benzenecarbothiamide (82020-41-5) → 4-(6-methoxybenzo[d]thiazol2-yl)-N,N-dimethylaniline (10205-71-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1055/s-2007-965929

Reference yield: 88.0%

C16H18N2OS (1217902-84-5) → 4-(6-methoxybenzo[d]thiazol2-yl)-N,N-dimethylaniline (10205-71-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

DOI:10.1055/s-0029-1217136

Reference yield: 85.0%

4-(dimethylamino)benzoyl chloride (4755-50-4) + 2-fluoro-4-(methoxy)aniline (458-52-6) → 4-(6-methoxybenzo[d]thiazol2-yl)-N,N-dimethylaniline (10205-71-7)

Guidance literature:

With Lawessons reagent; In diphenylether; for 3h; regioselective reaction; Inert atmosphere; Heating;

DOI:10.1055/s-0029-1218798

upstream raw materials:

acetic acid

4-dimethylamino-benzaldehyde

2-(4-aminophenyl)-6-methoxybenzothiazole

methyl iodide