Technology Process of Benzo[b]thiophene, 5,6-dimethoxy-2-(4-methoxyphenyl)-
There total 8 articles about Benzo[b]thiophene, 5,6-dimethoxy-2-(4-methoxyphenyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methoxyphenylboronic acid; C10H10Cl2O2S;
With
caesium carbonate; cesium fluoride;
In
tetrahydrofuran;
for 0.5h;
Inert atmosphere;
With
tris-(dibenzylideneacetone)dipalladium(0); bis[2-(diphenylphosphino)phenyl] ether;
In
tetrahydrofuran;
for 24h;
Reflux;
Inert atmosphere;
- Guidance literature:
-
2'-[4',5'-dimethoxy-2'-(tert-butyldimethylsilylsulfanyl)phenyl]-1,3-dithiane;
With
titanocene dichloride; magnesium; triethyl phosphite;
4A MS;
In
tetrahydrofuran;
for 0.25h;
Merrifield resin-CH2OC(O)C6H4-pOMe;
In
tetrahydrofuran;
With
trifluoroacetic acid; trifluoroacetic anhydride;
In
dichloromethane;
for 1.41667h;
DOI:10.1021/jo049344o
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 81 percent / iron; ammonium chloride / H2O; ethanol / 3.5 h / Heating
2.1: aq. HCl; sodium nitrite / H2O / 0.5 h / 0 - 5 °C
2.2: potassium ethyl xanthate / H2O / 0.83 h / 40 - 45 °C
2.3: 72 percent / LiAlH4 / tetrahydrofuran / 2 h
3.1: 77 percent / pyridine / CH2Cl2 / 20 °C
4.1: titanocene dichloride; magnesium; triethyl phosphite / 4A MS / tetrahydrofuran / 0.25 h
4.2: tetrahydrofuran
4.3: 30 percent / TFA; TFAA / CH2Cl2 / 1.42 h
With
pyridine; hydrogenchloride; titanocene dichloride; ammonium chloride; iron; magnesium; sodium nitrite; triethyl phosphite;
4A MS;
In
tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jo049344o
