2-methylthio-4-pyrimidinyl triflate

Base Information

• Chemical Name: 2-methylthio-4-pyrimidinyl triflate
• CAS No.: 154499-77-1
• Molecular Formula: C₆H₅F₃N₂O₃S₂
• Molecular Weight: 274.245
• Mol file: 154499-77-1.mol

Synonyms:

Chemical Property of 2-methylthio-4-pyrimidinyl triflate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methylthio-4-pyrimidinyl triflate

There total 1 articles about 2-methylthio-4-pyrimidinyl triflate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 2-(methylsulfanyl)pyrimidin-4-ol (5751-20-2,124700-70-5) → phenyl trifluoromethanesulfonamide (456-64-4) + 2-methylthio-4-pyrimidinyl triflate (154499-77-1)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 2 h, 2.) THF, 0 deg C, overnight;

DOI:10.3987/COM-93-S39

Reference yield: 68.0%

(E)-1-phenyl-(2-tributylstannyl)ethene (66680-87-3,66680-88-4,79159-76-5) + 2-methylthio-4-pyrimidinyl triflate (154499-77-1) → β-methylthio-4-β-styrylpyrimidine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In 1,4-dioxane; for 2h;

DOI:10.3987/COM-93-S39

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) + 2-methylthio-4-pyrimidinyl triflate (154499-77-1) → 4-(4-methoxyphenyl)-2-(methylsulfanyl)pyrimidine (148990-17-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; zinc dibromide; Yield given. Multistep reaction;

DOI:10.3987/COM-93-S39

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

2-(methylsulfanyl)pyrimidin-4-ol

Downstream raw materials:

4-(4-methoxyphenyl)-2-(methylsulfanyl)pyrimidine