(R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

• Chemical Name: (R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate
• CAS No.: 1425504-34-2
• Molecular Formula: C₃₄H₃₀N₆O₃
• Molecular Weight: 570.651
• Mol file: 1425504-34-2.mol

Synonyms:

Chemical Property of (R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate

There total 2 articles about (R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethoxypyridine (18677-48-0) + benzyl chloroformate (501-53-1,94274-21-2) → (R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate (1425504-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / acetonitrile / 0.83 h / 0 °C

1.2: 0.5 h / 0 °C

1.3: 3 h / 23 °C

2.1: acetic acid; 1-methyl-pyrrolidin-2-one / 6 h / 20 - 105 °C

With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; acetic acid; In acetonitrile;

DOI:10.1021/jm301658d

Reference yield:

benzyl 3-hydroxy-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate (811450-53-0) + (R)-N-(4-(1-aminoethyl)phenyl)-6-(pyridin-4-yl)quinazolin-2-amine (1213700-07-2) → (R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate (1425504-34-2)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; acetic acid; at 20 - 105 ℃; for 6h;

DOI:10.1021/jm301658d

Reference yield:

(R)-benzyl 5-oxo-3-(1-(4-(6-(pyridin-4-yl)quinazolin-2-yl-amino)phenyl)ethylamino)-5,6-dihydropyridine-1(2H)-carboxylate (1425504-34-2) → C26H24N6O (1425504-12-6)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; at 23 ℃; for 18h;

DOI:10.1021/jm301658d

upstream raw materials:

3,5-dimethoxypyridine

benzyl chloroformate

benzyl 3-hydroxy-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

(R)-N-(4-(1-aminoethyl)phenyl)-6-(pyridin-4-yl)quinazolin-2-amine

Downstream raw materials:

C₂₆H₂₄N₆O