Propanoic acid, 3-amino-3-imino-, methyl ester, monohydrochloride

Base Information

• Chemical Name: Propanoic acid, 3-amino-3-imino-, methyl ester, monohydrochloride
• CAS No.: 103173-54-2
• Molecular Formula: C4H8N2O2.ClH
• Molecular Weight: 152.581
• Hs Code.: 2922498590
• Mol file: 103173-54-2.mol

Synonyms:methyl 3-amino-3-iminopropanoate hydrochloride;amidinoacetic acid methyl ester hydrochloride;methyl amidinoacetate hydrochloride;

Chemical Property of Propanoic acid, 3-amino-3-imino-, methyl ester, monohydrochloride

Chemical Property:

• PSA: 76.17000
• LogP: 1.08750

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-Amino-3-iminopropanoateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 3-amino-3-imino-, methyl ester, monohydrochloride

There total 1 articles about Propanoic acid, 3-amino-3-imino-, methyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + ethyl amidinoacetate (50551-10-5) → carbethoxyacetamidine hydrochloride (57508-48-2) + amidino-acetic acid methyl ester hydrochloride (103173-54-2)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1016/j.tet.2008.11.064

Reference yield: 39.0%

pyridine-4-carbonitrile (100-48-1) + diethyl (3-methylbutyl)phosphonate (90795-87-2) + 3,5-difluorobenzaldehyde (32085-88-4) + amidino-acetic acid methyl ester hydrochloride (103173-54-2) → [4-(3,5-difluoro-phenyl)-5-isobutyl-6-pyridin-4-yl-pyrimidin-2-yl]-acetic acid methyl ester

Guidance literature:

pyridine-4-carbonitrile; diethyl (3-methylbutyl)phosphonate; With n-butyllithium; In 1,4-dioxane; hexane; at -30 ℃; for 0.5h;

3,5-difluorobenzaldehyde; In 1,4-dioxane; hexane; at -30 - 40 ℃; for 2h;

amidino-acetic acid methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; hexane; for 6h; Heating;

DOI:10.1016/j.tetlet.2005.01.068

Reference yield:

ethyl 2-[(3,4-dichlorophenyl)methyl]-4,4,4-trifluoro-3-oxobutanoate + amidino-acetic acid methyl ester hydrochloride (103173-54-2) → methyl [5-(3,4-dichlorobenzyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl]acetate

Guidance literature:

amidino-acetic acid methyl ester hydrochloride; With sodium methylate; In methanol; at 23 ℃; for 0.25h; Inert atmosphere;

ethyl 2-[(3,4-dichlorophenyl)methyl]-4,4,4-trifluoro-3-oxobutanoate; In methanol; for 16.5h; Reflux; Inert atmosphere;

upstream raw materials:

methanol

ethyl amidinoacetate

Downstream raw materials:

3-Methyl 5-[2-(4,4-diphenylpiperid-1-yl)-ethyl] 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate

Refernces