3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, 3-ethyl 5-(1-methylethyl) ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, 3-ethyl 5-(1-methylethyl) ester
• CAS No.: 103198-43-2
• Molecular Formula: C₃₀H₃₀Cl₂N₂O₇
• Molecular Weight: 601.483
• Mol file: 103198-43-2.mol

Synonyms:

Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, 3-ethyl 5-(1-methylethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, 3-ethyl 5-(1-methylethyl) ester

There total 2 articles about 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, 3-ethyl 5-(1-methylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

isopropyl 3-aminocrotonate (40100-28-5) + ethyl 4-[2-(phthalimido)ethoxy]acetoacetate (88150-75-8) + 2,3-dichlorobenzylaldehyde (6334-18-5) → 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester (103198-43-2)

Guidance literature:

Heating;

DOI:10.1016/0223-5234(91)90132-7

Reference yield:

isopropyl acetoacetate (542-08-5) → 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester (103198-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / ethanol

2: 8 percent / Heating

With ammonia; In ethanol;

DOI:10.1016/0223-5234(91)90132-7

Reference yield:

4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester (103198-43-2) → 2-(2-Amino-ethoxymethyl)-4-(2,3-dichloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester (103198-57-8)

Guidance literature:

With methylamine; In ethanol; Ambient temperature;

DOI:10.1016/0223-5234(91)90132-7

upstream raw materials:

isopropyl 3-aminocrotonate

ethyl 4-[2-(phthalimido)ethoxy]acetoacetate

2,3-dichlorobenzylaldehyde

isopropyl acetoacetate

Downstream raw materials:

2-(2-Amino-ethoxymethyl)-4-(2,3-dichloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester