1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene

Base Information

• Chemical Name: 1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene
• CAS No.: 915141-52-5
• Molecular Formula: C₂₅H₄₆O₄Si₂
• Molecular Weight: 466.809
• Mol file: 915141-52-5.mol

Synonyms:

Chemical Property of 1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene

There total 2 articles about 1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3S,4R,5R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-2-one (915141-50-3) + chloro-trimethyl-silane (75-77-4) → 1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene (915141-52-5)

Guidance literature:

With triethylamine; lithium hexamethyldisilazane;

DOI:10.1055/s-2006-949614

Reference yield:

(+)-[2S-(2R*,3S*,4S*)]-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide (151058-21-8) → 1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene (915141-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Et₃N; LiHMDS

With triethylamine; lithium hexamethyldisilazane;

DOI:10.1055/s-2006-949614

Reference yield: 75.0%

2-[(2S,4S,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]acetaldehyde (915141-48-9) + 1-{(1R,2S)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-3-trimethylsilanyloxy-but-3-enyloxymethyl}-4-methoxy-benzene (915141-52-5) → (2S,5S,6R,7R)-1-[(2S,4R,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-8-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-5,7-dimethyl-octan-4-one + (2R,5S,6R,7R)-1-[(2S,4R,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-8-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-5,7-dimethyl-octan-4-one (915141-54-7)

Guidance literature:

With boron trifluoride diethyl etherate;

DOI:10.1055/s-2006-949614

upstream raw materials:

(3S,4R,5R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-2-one

chloro-trimethyl-silane

(+)-[2S-(2R*,3S*,4S*)]-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

Downstream raw materials:

(2R,5S,6R,7R)-1-[(2S,4R,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-8-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-5,7-dimethyl-octan-4-one

(2R,5S,6R,7R)-1-[(2S,4S,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-2,8-bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,7-dimethyl-octan-4-one