4-Methoxy-4'-trifluoromethyl-biphenyl

Base Information

• Chemical Name: 4-Methoxy-4'-trifluoromethyl-biphenyl
• CAS No.: 10355-12-1
• Molecular Formula: C14H11F3O
• Molecular Weight: 252.236
• DSSTox Substance ID: DTXSID50458794
• Nikkaji Number: J604.150G
• Wikidata: Q82282318
• Mol file: 10355-12-1.mol

Synonyms:4-METHOXY-4'-TRIFLUOROMETHYL-BIPHENYL;4-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl;10355-12-1;SCHEMBL3992142;DTXSID50458794;KQXWJYJLFZWYHI-UHFFFAOYSA-N;AKOS015967374;4'-(Trifluoromethyl)-4-methoxybiphenyl;1-(4-methoxyphenyl)-4-(trifluoromethyl)-benzene

Chemical Property of 4-Methoxy-4'-trifluoromethyl-biphenyl

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 252.07619946
• Heavy Atom Count: 18
• Complexity: 248

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F

Technology Process of 4-Methoxy-4'-trifluoromethyl-biphenyl

There total 24 articles about 4-Methoxy-4'-trifluoromethyl-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Iodobenzotrifluoride (455-13-0) + tris(4-methoxyphenyl)bismuth (33397-21-6) → 1-(4-methoxyphenyl)-4-(trifluoromethyl)benzene (10355-12-1) + 4,4'-Dimethoxybiphenyl (2132-80-1)

Guidance literature:

With caesium carbonate; triphenylphosphine; palladium dichloride; In N,N-dimethyl acetamide; at 90 ℃; for 1h;

DOI:10.1016/j.tet.2008.04.011

Reference yield: 72.0%

p-trifluoromethylphenyl bromide (402-43-7) + tris(4-methoxyphenyl)bismuth (33397-21-6) → 1-(4-methoxyphenyl)-4-(trifluoromethyl)benzene (10355-12-1) + 4,4'-Dimethoxybiphenyl (2132-80-1)

Guidance literature:

With caesium carbonate; triphenylphosphine; palladium dichloride; In N,N-dimethyl acetamide; at 90 ℃; for 2h;

DOI:10.1016/j.tet.2008.04.011

Reference yield: 70.0%

1-bromo-4-methoxy-benzene (104-92-7) + p-trifluoromethylphenyl bromide (402-43-7) → 4,4'-bis(trifluoromethyl)biphenyl (581-80-6) + 1-(4-methoxyphenyl)-4-(trifluoromethyl)benzene (10355-12-1) + 4,4'-Dimethoxybiphenyl (2132-80-1)

Guidance literature:

1-bromo-4-methoxy-benzene; p-trifluoromethylphenyl bromide; With magnesium; In tetrahydrofuran; at 20 ℃; for 2h;

With synthetic air; cobalt(II) chloride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1055/s-0029-1218013

upstream raw materials:

1-bromo-4-methoxy-benzene

4-chloromethoxybenzene

4-chlorobenzotrifluoride

4-Iodobenzotrifluoride

Downstream raw materials:

4-hydroxy-4'-trifluoromethylbiphenyl

[4-hydroxy-4'-(trifluoromethyl)biphenyl]-3-carboxylic acid

4-(4-tolyl)anisole