N,N-diethylcyclopropanecarboxamide

Base Information

• Chemical Name: N,N-diethylcyclopropanecarboxamide
• CAS No.: 10374-28-4
• Molecular Formula: C8H15NO
• Molecular Weight: 141.213
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID70408837
• Nikkaji Number: J1.765.235D
• Wikidata: Q82214444
• Mol file: 10374-28-4.mol

Synonyms:N,N-diethylcyclopropanecarboxamide;10374-28-4;MFCD00760286;Cyclopropanecarboxamide, N,N-diethyl-;SCHEMBL1289738;AMY5434;DTXSID70408837;Cyclopropyl-N,N-diethylcarboxamide;CS1122;AKOS003041311;AC-31162;AS-77867;SY069853;CS-0016514;FT-0709978;A896367

Chemical Property of N,N-diethylcyclopropanecarboxamide

Chemical Property:

• Boiling Point: 224.1±7.0 °C(Predicted)
• PKA: -0.47±0.20(Predicted)
• PSA: 20.31000
• Density: 0.999±0.06 g/cm3(Predicted)
• LogP: 1.26480
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 141.115364102
• Heavy Atom Count: 10
• Complexity: 125

Purity/Quality:

97% ^*data from raw suppliers

N,N-Diethylcyclopropanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C(=O)C1CC1

Technology Process of N,N-diethylcyclopropanecarboxamide

There total 4 articles about N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

diethylamine (109-89-7) + cyclopropanecarboxylic acid (1759-53-1) → cyclopropanecarboxylic acid diethylamide (10374-28-4)

Guidance literature:

cyclopropanecarboxylic acid; With thionyl chloride; at 0 - 20 ℃;

diethylamine; In dichloromethane; at 25 ℃;

DOI:10.1021/op0341871

Reference yield: 33.9%

→ cyclopropanecarboxylic acid diethylamide (10374-28-4)

Guidance literature:

Reference yield:

cyclopropanecarboxylic acid chloride (4023-34-1) + diethylamine (109-89-7) → cyclopropanecarboxylic acid diethylamide (10374-28-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.joc.7b00945

upstream raw materials:

cyclopropanecarboxylic acid n-butyl ester

diethylamine

cyclopropanecarboxylic acid

cyclopropanecarboxylic acid chloride

Downstream raw materials:

(±)-(cis)-2-iodocyclopropyl-N,N-diethylcarboxamide

1-methyl-cyclopropanecarboxylic acid diethylamide

1-cyclopropyl-2-(2-fluorophenyl)ethanone

N-phenylcyclopropanecarboxamide