N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide

Base Information

• Chemical Name: N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide
• CAS No.: 243459-23-6
• Molecular Formula: C₂₆H₃₆FNO₄Si₂
• Molecular Weight: 501.746
• Mol file: 243459-23-6.mol

Synonyms:

Chemical Property of N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide

There total 4 articles about N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorophthalic anhydride (319-03-9) → N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide (243459-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 4 h / Heating

2: BBr₃ / CH₂Cl₂ / 8 h

3: imidazole / CH₂Cl₂

With 1H-imidazole; boron tribromide; In dichloromethane; acetic acid;

DOI:10.1246/cl.2001.762

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide (243459-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 4 h / Heating

2: BBr₃ / CH₂Cl₂ / 8 h

3: imidazole / CH₂Cl₂

With 1H-imidazole; boron tribromide; In dichloromethane; acetic acid;

DOI:10.1246/cl.2001.762

Reference yield:

2-(3,5-dimethoxy-phenyl)-5-fluoro-isoindole-1,3-dione (343781-11-3) → N-[3,5-di(tert-butyldimethylsilyloxy)phenyl]-4-fluorophthalimide (243459-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: BBr₃ / CH₂Cl₂ / 8 h

2: imidazole / CH₂Cl₂

With 1H-imidazole; boron tribromide; In dichloromethane;

DOI:10.1246/cl.2001.762

upstream raw materials:

tert-butyldimethylsilyl chloride

2-(3,5-dihydroxy-phenyl)-5-fluoro-isoindole-1,3-dione

4-fluorophthalic anhydride

3.5-dimethoxyaniline