2-chloro-N-[5-(4-methoxybenzyl)-1,3-thiazol-2-yl]acetamide

Base Information

• Chemical Name: 2-chloro-N-[5-(4-methoxybenzyl)-1,3-thiazol-2-yl]acetamide
• CAS No.: 304895-22-5
• Molecular Formula: C₁₃H₁₃ClN₂O₂S
• Molecular Weight: 296.777
• DSSTox Substance ID: DTXSID101186917
• Mol file: 304895-22-5.mol

Synonyms:304895-22-5;2-chloro-N-[5-(4-methoxybenzyl)-1,3-thiazol-2-yl]acetamide;2-chloro-N-{5-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-yl}acetamide;2-chloro-N-[5-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-yl]acetamide;DTXSID101186917;STK952089;AKOS000628222;CS-0247021;EN300-35348;SR-01000369565;SR-01000369565-1;Z57086064;2-Chloro-N-[5-[(4-methoxyphenyl)methyl]-2-thiazolyl]acetamide

Chemical Property of 2-chloro-N-[5-(4-methoxybenzyl)-1,3-thiazol-2-yl]acetamide

Chemical Property:

• PKA: 7.22±0.50(Predicted)
• Density: 1.348±0.06 g/cm3(Predicted)
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 296.0386265
• Heavy Atom Count: 19
• Complexity: 298

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-N-[5-(4-METHOXYBENZYL)-1,3-THIAZOL-2-YL]ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC2=CN=C(S2)NC(=O)CCl

Technology Process of 2-chloro-N-[5-(4-methoxybenzyl)-1,3-thiazol-2-yl]acetamide

There total 4 articles about 2-chloro-N-[5-(4-methoxybenzyl)-1,3-thiazol-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

chloroacetyl chloride (79-04-9) + 5-[(4-methoxyphenyl)methyl]thiazol-2-amine (299953-06-3) → 2-chloro-N-[5-[(4-methoxyphenyl)methyl]thiazol-2-yl]acetamide (304895-22-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.5b01517

Reference yield:

para-methoxyphenyldiazonium chloride (4346-59-2) → 2-chloro-N-[5-[(4-methoxyphenyl)methyl]thiazol-2-yl]acetamide (304895-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; magnesium oxide / water / pH 6 - 7

1.2: 20 °C / pH 6 - 7

2.1: ethanol / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 0 - 20 °C

With magnesium oxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In ethanol; water; acetonitrile; 1.2: |Meerwein Arylation;

DOI:10.1021/acs.jmedchem.5b01517

Reference yield:

2-chloro-3-(4-methoxyphenyl)propanal (807667-27-2) → 2-chloro-N-[5-[(4-methoxyphenyl)methyl]thiazol-2-yl]acetamide (304895-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; In ethanol; acetonitrile;

DOI:10.1021/acs.jmedchem.5b01517

upstream raw materials:

chloroacetyl chloride

5-[(4-methoxyphenyl)methyl]thiazol-2-amine

4-methoxy-aniline

para-methoxyphenyldiazonium chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 304895-22-5 2-CHLORO-N-[5-(4-METHOXYBENZYL)-1,3-THIAZOL-2-YL]ACETAMIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send