C₃₆H₄₇N₃O₄

Base Information

• Chemical Name: C₃₆H₄₇N₃O₄
• CAS No.: 1384259-02-2
• Molecular Formula: C₃₆H₄₇N₃O₄
• Molecular Weight: 585.787
• Mol file: 1384259-02-2.mol

Synonyms:

Chemical Property of C₃₆H₄₇N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₄₇N₃O₄

There total 5 articles about C₃₆H₄₇N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-dimethyl-1,4-butanediamine (16011-97-5) + 7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid, 13-cyclohexyl-3-methoxy-, 10-(1,1-dimethylethyl) ester (1038924-00-3) → C36H47N3O4 (1384259-02-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201200110

Reference yield:

1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester (879498-90-5) → C36H47N3O4 (1384259-02-2)

Guidance literature:

Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 70 °C

2: caesium carbonate / N,N-dimethyl-formamide / 60 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With bis-triphenylphosphine-palladium(II) chloride; water; potassium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.04.113

Reference yield:

2-formyl-4-methoxyphenylboronic acid (139962-95-1) → C36H47N3O4 (1384259-02-2)

Guidance literature:

Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 70 °C

2: caesium carbonate / N,N-dimethyl-formamide / 60 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With bis-triphenylphosphine-palladium(II) chloride; water; potassium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.04.113

upstream raw materials:

N,N'-dimethyl-1,4-butanediamine

7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid, 13-cyclohexyl-3-methoxy-, 10-(1,1-dimethylethyl) ester

13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

tert-butyl 3-cyclohexyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-6-carboxylate

Downstream raw materials:

11H-2,18-methano-3,7:4,1-dimetheno-10,2,9,11,16-benzothiatetraazacycloheneicosine-8,17(9H,12H)-dione, 26-cyclohexyl-13,14,15,16-tetrahydro-21-methoxy-11,16-dimethyl-, 10,10-dioxide

C₃₂H₄₀N₄O₆S

C₃₆H₄₈N₄O₆S