Technology Process of 7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid, 13-cyclohexyl-3-methoxy-, 10-(1,1-dimethylethyl) ester
There total 12 articles about 7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid, 13-cyclohexyl-3-methoxy-, 10-(1,1-dimethylethyl) ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester;
With
tetra(n-butyl)ammonium hydroxide; water;
In
tetrahydrofuran; methanol;
at 20 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 70 °C
2: caesium carbonate / N,N-dimethyl-formamide / 60 °C
3: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; water; potassium carbonate; caesium carbonate; lithium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.04.113
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C
2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.67 h / 0 - 20 °C
3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux
3.2: 1 h / 0 - 20 °C
4.1: silver carbonate / dichloromethane / 0 - 20 °C / Molecular sieve
5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; toluene / 0.25 h
5.2: 4 h / 85 °C
6.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
7.1: tetra(n-butyl)ammonium hydroxide; water / tetrahydrofuran; methanol / 20 °C
With
triethylsilane; lithium hydroxide; pyridinium hydrobromide perbromide; tetra(n-butyl)ammonium hydroxide; water; sodium carbonate; caesium carbonate; silver carbonate; trifluoroacetic acid; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
![13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester](/Databaselist/images/loading.webp)
