1,3-diphenylbutan-2-one

Base Information

• Chemical Name: 1,3-diphenylbutan-2-one
• CAS No.: 13363-25-2
• Molecular Formula: C16H16 O
• Molecular Weight: 224.302
• Mol file: 13363-25-2.mol

Synonyms:1,3-Diphenyl-2-butanone;NSC 406966

Chemical Property of 1,3-diphenylbutan-2-one

Chemical Property:

• Vapor Pressure: 0.000193mmHg at 25°C
• Boiling Point: 328.2°C at 760 mmHg
• Flash Point: 139.1°C
• Density: 1.048g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-diphenylbutan-2-one

There total 20 articles about 1,3-diphenylbutan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 1,3-Diphenylpropanone (102-04-5) → 1,3-diphenylbutan-2-one (13363-25-2)

Guidance literature:

With C₃₄H₂₇IrN₂P⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); caesium carbonate; at 65 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201405990

Reference yield: 73.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + phenylacetaldehyde (122-78-1) → 1,3-diphenylbutan-2-one (13363-25-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.6b00024

Reference yield: 70.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 2-phenylethanol (60-12-8) → 1,3-diphenylbutan-2-one (13363-25-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; 1,3-di(adamantan-1-yl)-1H-imidazol-3-ium chloride; In 1,4-dioxane; toluene; at 110 ℃; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.orglett.0c02340

upstream raw materials:

2-hydroxy-1.3-diphenyl-butane

1-phenylethyl cyanide

benzylmagnesium chloride

sodium methylate

Downstream raw materials:

2-hydroxy-1.3-diphenyl-butane

1-benzyl-2-phenyl-propylamine

2,3-diphenylbutane

1-methyl-4-(1-phenylethyl)benzene

Refernces

• 1、 Thompson,Huegi. "". . p. 636. Retrieved 1973.
• 2、 Yang, Peng-Fei,Shu, Wei. "Direct Synthesis of Mono-α-arylated Ketones from Alcohols and Olefins via Ni-Catalyzed Oxidative Cross-Coupling". supporting information. p. 6203 - 6208. Retrieved 2020/08/12.
• 3、 Xiao, Li-Jun,Fu, Xiao-Ning,Zhou, Min-Jie,Xie, Jian-Hua,Wang, Li-Xin,Xu, Xiu-Fang,Zhou, Qi-Lin. "Nickel-Catalyzed Hydroacylation of Styrenes with Simple Aldehydes: Reaction Development and Mechanistic Insights". supporting information. p. 2957 - 2960. Retrieved 2016/03/19.