(2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester

Base Information

• Chemical Name: (2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester
• CAS No.: 120829-07-4
• Molecular Formula: C₅₂H₉₁N₇O₁₃
• Molecular Weight: 1022.33

Synonyms:

Chemical Property of (2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester

There total 12 articles about (2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Ser(tBu)-OH (71989-33-8) → (2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester (120829-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 48 h

2: morpholine / 0.67 h / Ambient temperature

With morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;

Reference yield:

benzyl bromide (100-39-0) → (2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester (120829-07-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) Cs₂CO₃ / 1.) EtOH/H₂O, 20 min; 2.) DMF, room temp., 2 h

2: morpholine / 0.67 h

3: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 18 h

4: morpholine / 0.67 h

5: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 18 h

6: morpholine / 0.67 h

7: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 22 h

8: morpholine / 0.67 h / Ambient temperature

9: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 48 h

10: morpholine / 0.67 h / Ambient temperature

With morpholine; caesium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;

Reference yield:

Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) → (2S,3R)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-tert-butoxy-propionylamino)-3-tert-butoxy-butyrylamino]-6-tert-butoxycarbonylamino-hexanoylamino}-6-tert-butoxycarbonylamino-hexanoylamino)-3-tert-butoxy-butyric acid benzyl ester (120829-07-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) Cs₂CO₃ / 1.) EtOH/H₂O, 20 min; 2.) DMF, room temp., 2 h

2: morpholine / 0.67 h

3: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 18 h

4: morpholine / 0.67 h

5: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 18 h

6: morpholine / 0.67 h

7: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 22 h

8: morpholine / 0.67 h / Ambient temperature

9: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 48 h

10: morpholine / 0.67 h / Ambient temperature

With morpholine; caesium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;

upstream raw materials:

O-tert-Butyl-N-(9-fluorenylmethoxycarbonyl)-L-seryl-O-tert-butyl-L-threonyl-N^ε-(tert-butoxycarbonyl)-L-lysyl-N^ε-(tert-butoxycarbonyl)-L-lysyl-O-tert-butyl-L-threonin-benzylester

Fmoc-Ser(tBu)-OH

benzyl bromide

Fmoc-Thr(tBu)-OH

Downstream raw materials:

O-tert-Butyl-N-(9-fluorenylmethoxycarbonyl)-L-seryl-O-tert-butyl-L-seryl-O-tert-butyl-L-threonyl-N^ε-(tert-butoxycarbonyl)-L-lysyl-N^ε-(tert-butoxycarbonyl)-L-lysyl-O-tert-butyl-L-threonin-benzylester

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