acotiaMide iMpurity

Base Information

Chemical Name:acotiaMide iMpurity
CAS No.:1809272-85-2
Molecular Formula:C₁₃H₁₂N₂O₆S
Molecular Weight:324.314
Hs Code.:

Synonyms:

Suppliers and Price of acotiaMide iMpurity

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylicAcid
5mg
$ 150.00

Total 15 raw suppliers

Chemical Property of acotiaMide iMpurity

Chemical Property:

PKA:3.36±0.10(Predicted)
Density:1.544±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic Acid is an impurity of Acotiamide (A190260), an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats. Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

Technology Process of acotiaMide iMpurity

There total 4 articles about acotiaMide iMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid ethyl ester

: 1809272-85-2
2-[N-(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid

Guidance literature:: With methanol; sodium hydroxide; at 0 - 20 ℃;

Reference yield:

: 490-64-2
asaronic acid

: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid ethyl ester

: 1809272-85-2
2-[N-(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / toluene / 2 h / 80 - 85 °C / Large scale

2: pyridine / dichloromethane / 1.83 h / 0 °C / Reflux; Large scale

3: pyridine; pyridine hydrochloride; water / N,N-dimethyl-formamide / 8 h / Reflux; Inert atmosphere; Large scale

With pyridine; thionyl chloride; water; pyridine hydrochloride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.oprd.5b00256

Reference yield:

: 42833-66-9
2,4,5-trimethoxybenzoyl chloride

: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid ethyl ester

: 1809272-85-2
2-[N-(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1.83 h / 0 °C / Reflux; Large scale

2: pyridine; pyridine hydrochloride; water / N,N-dimethyl-formamide / 8 h / Reflux; Inert atmosphere; Large scale

With pyridine; water; pyridine hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.oprd.5b00256