erythro-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide

Base Information

• Chemical Name: erythro-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide
• CAS No.: 89121-81-3
• Molecular Formula: Br*C₂₉H₃₀OP
• Molecular Weight: 505.434
• Mol file: 89121-81-3.mol

Synonyms:

Chemical Property of erythro-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide

There total 5 articles about erythro-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

n-butyl(triphenyl)phosphonium bromide (1779-51-7) + benzaldehyde (100-52-7) → threo-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide (89121-80-2,89121-81-3)

Guidance literature:

With n-butyllithium; hydrogen bromide; In tetrahydrofuran; hexane; at -45 ℃; for 0.25h;

DOI:10.1021/ja00284a034

Reference yield: 44.0%

n-butyl(triphenyl)phosphonium bromide (1779-51-7) + benzaldehyde (100-52-7) → erythro-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide (89121-80-2,89121-81-3)

Guidance literature:

With hydrogen bromide; sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

DOI:10.1021/ja00284a034

Reference yield:

n-butyl(triphenyl)phosphonium bromide (1779-51-7) + benzaldehyde (100-52-7) → threo-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide (89121-80-2,89121-81-3) + erythro-(1-hydroxy-1-phenyl-2-pentyl)triphenylphosphonium bromide (89121-80-2,89121-81-3)

Guidance literature:

With n-butyllithium; hydrogen bromide; Yield given. Multistep reaction; 1.) -78 deg C, hexane; 2.);

DOI:10.1021/ja00318a073

upstream raw materials:

n-butyl(triphenyl)phosphonium bromide

benzaldehyde

Downstream raw materials:

(3R,4S)-2,2,2,4-Tetraphenyl-3-propyl-2λ⁵-[1,2]oxaphosphetane

(Z)-pent-1-en-1-ylbenzene

(E)-1-phenyl-1-pentene

benzaldehyde