(S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide

Base Information

Chemical Name:(S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide
CAS No.:1363368-24-4
Molecular Formula:C₂₂H₂₂N₄O₃
Molecular Weight:390.442
Hs Code.:

Synonyms:

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Chemical Property of (S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide

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Technology Process of (S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide

There total 11 articles about (S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75867-41-3
4-trimethylsilanylethynyl-benzoic acid methyl ester

: 1363368-24-4
(S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; methanol / 3 h / 20 °C / Inert atmosphere

2.1: pyridine / copper diacetate / methanol / 48 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; methanol / 1 h / 20 °C / Reflux

3.2: pH 2

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride; sodium methylate; methanol / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; methanol; hydroxylamine hydrochloride; sodium methylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; copper diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 619-44-3
methyl 4-iodobenzoate

: 1363368-24-4
(S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 22 h / 60 °C / Inert atmosphere; Sealed vessel

2.1: potassium carbonate; methanol / 3 h / 20 °C / Inert atmosphere

3.1: pyridine / copper diacetate / methanol / 48 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide; methanol / 1 h / 20 °C / Reflux

4.2: pH 2

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; sodium methylate; methanol / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; methanol; hydroxylamine hydrochloride; sodium methylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 3034-86-4
4-ethynylbenzoic acid methyl ester

: 1363368-24-4
(S)-N-(3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yI)-4-(4-(2-aminophenyl)buta-1,3-diynyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / copper diacetate / methanol / 48 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; methanol / 1 h / 20 °C / Reflux

2.2: pH 2

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; sodium methylate; methanol / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; methanol; hydroxylamine hydrochloride; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; copper diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;