(S)-3-methyl-3-nitro-2-((S)-1-phenylethylamino)butanoic acid

Base Information

• Chemical Name: (S)-3-methyl-3-nitro-2-((S)-1-phenylethylamino)butanoic acid
• CAS No.: 1093192-03-0
• Molecular Formula: C₁₃H₁₈N₂O₄
• Molecular Weight: 266.297
• Mol file: 1093192-03-0.mol

Synonyms:(S)-3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoic acid

Chemical Property of (S)-3-methyl-3-nitro-2-((S)-1-phenylethylamino)butanoic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-Methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-methyl-3-nitro-2-((S)-1-phenylethylamino)butanoic acid

There total 2 articles about (S)-3-methyl-3-nitro-2-((S)-1-phenylethylamino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

2-nitropropane (79-46-9) + (S)-1-phenyl-ethylamine (2627-86-3) + Glyoxilic acid (298-12-4) → (S)-3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoic acid (1093192-03-0)

Guidance literature:

In water; at 20 - 45 ℃; for 8h;

DOI:10.1016/j.bmcl.2017.12.005

Reference yield:

2-nitropropane (79-46-9) + (S)-1-phenyl-ethylamine (2627-86-3) + 2-oxo-propionic acid (127-17-3) → (S)-3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoic acid (1093192-03-0)

Guidance literature:

2-nitropropane; With potassium hydroxide; In water; at 45 ℃; Inert atmosphere;

(S)-1-phenyl-ethylamine; 2-oxo-propionic acid; In water; at 35 - 46 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 12h;

Reference yield: 96.0%

(S)-3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoic acid (1093192-03-0) + methyl iodide (74-88-4) → (S)-methyl 3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoate (1093192-04-1)

Guidance literature:

(S)-3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoic acid; With caesium carbonate; In N,N-dimethyl-formamide; for 0.166667h; Sonication for 1 min;

methyl iodide; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 2.41667h;

upstream raw materials:

2-nitropropane

(S)-1-phenyl-ethylamine

Glyoxilic acid

2-oxo-propionic acid

Downstream raw materials:

(S)-methyl 3-methyl-3-nitro-2-(((S)-1-phenylethyl)amino)butanoate

(S)-methyl 3-amino-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate

(S)-methyl 3-((tert-butoxycarbonyl)amino)-3-methyl-2-(((S)-1-phenylethyl)amino)butanoate

(S)-2-amino-3-(tert-butoxycarbonylamino)-3-methylbutanoic acid methyl ester