N₁-(4-bromophenyl)-N₁-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-N₅-phenyl-N₅-[1-(2-phenylethyl)piperidin-4-yl]pentanediamide

Base Information

• Chemical Name: N₁-(4-bromophenyl)-N₁-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-N₅-phenyl-N₅-[1-(2-phenylethyl)piperidin-4-yl]pentanediamide
• CAS No.: 1379800-14-2
• Molecular Formula: C₄₄H₅₁BrN₄O₃
• Molecular Weight: 763.818
• Mol file: 1379800-14-2.mol

Synonyms:

Chemical Property of N₁-(4-bromophenyl)-N₁-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-N₅-phenyl-N₅-[1-(2-phenylethyl)piperidin-4-yl]pentanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(4-bromophenyl)-N₁-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-N₅-phenyl-N₅-[1-(2-phenylethyl)piperidin-4-yl]pentanediamide

There total 2 articles about N₁-(4-bromophenyl)-N₁-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-N₅-phenyl-N₅-[1-(2-phenylethyl)piperidin-4-yl]pentanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Cyclohexyl isocyanide (931-53-3) + 5-oxo-5-((1-phenethylpiperidin-4-yl)(phenyl)amino)pentanoic acid (526191-19-5) + benzaldehyde (100-52-7) + 4-bromo-aniline (106-40-1) → N1-(4-bromophenyl)-N1-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-N5-phenyl-N5-[1-(2-phenylethyl)piperidin-4-yl]pentanediamide (1379800-14-2)

Guidance literature:

benzaldehyde; 4-bromo-aniline; In methanol; at 20 ℃; for 0.5h;

5-oxo-5-((1-phenethylpiperidin-4-yl)(phenyl)amino)pentanoic acid; In methanol; for 0.25h;

Cyclohexyl isocyanide; In methanol; for 24h;

DOI:10.1002/hlca.201100392

Reference yield:

glutaric anhydride, (108-55-4) → N1-(4-bromophenyl)-N1-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]-N5-phenyl-N5-[1-(2-phenylethyl)piperidin-4-yl]pentanediamide (1379800-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chloroform / 20 °C

2.1: methanol / 0.5 h / 20 °C

2.2: 0.25 h

2.3: 24 h

In methanol; chloroform; 2.1: Ugi condensation / 2.2: Ugi condensation / 2.3: Ugi condensation;

DOI:10.1002/hlca.201100392

upstream raw materials:

glutaric anhydride,

Cyclohexyl isocyanide

5-oxo-5-((1-phenethylpiperidin-4-yl)(phenyl)amino)pentanoic acid

benzaldehyde