(R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether

Base Information

Chemical Name:(R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether
CAS No.:191476-10-5
Molecular Formula:C₃₀H₅₀O₂Si₂
Molecular Weight:498.897
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether

Chemical Property:

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Technology Process of (R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether

There total 5 articles about (R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 147974-22-9
(R)-8-hydroxyoctan-2-ol-8-tert-butyldiphenylsilyl ether

: 191476-10-5
(R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 4h; Yield given;
DOI:10.1016/S0957-4166(97)00186-9

Reference yield:

: 629-30-1
1,7-heptandiol

: 191476-10-5
(R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / imidazole / dimethylformamide / 24 h / 25 °C

2: 93 percent / Dess-Martin periodinane / CH₂Cl₂ / 12 h / 25 °C

3: tricarbonyl chromium⁽⁰⁾ (1R,2S)-N,N-dibutylnorephedrine / toluene / 36 h / 5 °C

4: 2,6-lutidine / CH₂Cl₂ / 4 h / -78 °C

With 1H-imidazole; 2,6-dimethylpyridine; tricarbonyl chromium⁽⁰⁾ (1R,2S)-N,N-dibutylnorephedrine; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0957-4166(97)00186-9

Reference yield:

: 147974-19-4
7-((tert-butyldiphenylsilyl)oxy)heptanal

: 191476-10-5
(R)-8-tert-butyldiphenylsiloxy-2-octanol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: tricarbonyl chromium⁽⁰⁾ (1R,2S)-N,N-dibutylnorephedrine / toluene / 36 h / 5 °C

2: 2,6-lutidine / CH₂Cl₂ / 4 h / -78 °C

With 2,6-dimethylpyridine; tricarbonyl chromium⁽⁰⁾ (1R,2S)-N,N-dibutylnorephedrine; In dichloromethane; toluene;
DOI:10.1016/S0957-4166(97)00186-9