threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid

Base Information

Chemical Name:threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid
CAS No.:99210-76-1
Molecular Formula:C₁₀H₁₃NO₅S
Molecular Weight:259.283
Hs Code.:

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Chemical Property of threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid

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Technology Process of threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid

There total 1 articles about threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 5398-77-6
para-methanesulfonylbenzaldehyde

: 56-40-6,18875-39-3,25718-94-9
glycine

: 31925-26-5,34029-28-2,50731-17-4,99210-76-1,144994-00-3
threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid

Guidance literature:: para-methanesulfonylbenzaldehyde; glycine; With sodium hydroxide; In ethanol; dichloromethane; at 0 - 20 ℃;

With hydrogenchloride; In water; at 20 ℃; for 1h; Cooling with ice;
DOI:10.1002/ejoc.201800658

Reference yield: 37.2%

: 31925-26-5,34029-28-2,50731-17-4,99210-76-1,144994-00-3
threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid

: (2S,3R)-3-[p-(methylsulfonyl)phenyl]-3-hydroxy-2-aminopropanoic acid

Guidance literature:: With pyridoxal 5'-phosphate; D-threonine aldolase from Delftia sp. RIT₃₁₃ cloned and expressed in Escherichia coli BL₂₁; sodium hydroxide; manganese(ll) chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; In dichloromethane; at 30 ℃; for 12h; Solvent; enantioselective reaction; Resolution of racemate; Enzymatic reaction;
DOI:10.1039/c7cy01774j

Reference yield: 31.0%

: 64-17-5
ethanol

: 87-69-4,138508-61-9
L-Tartaric acid

: 31925-26-5,34029-28-2,50731-17-4,99210-76-1,144994-00-3
threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid

: (2S,3R)-ethyl 2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoate L-tartaric acid salt

Guidance literature:: ethanol; threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid; With thionyl chloride; at 0 - 60 ℃; for 8h;

L-Tartaric acid; In methanol; at 20 - 60 ℃; for 2h;
DOI:10.1002/ejoc.201800658