{(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:{(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:195717-72-7
Molecular Formula:C₄₇H₅₅N₃O₆Si
Molecular Weight:786.056
Hs Code.:

{(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of {(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of {(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 10 articles about {(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 195717-72-7
{(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride / 65 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C

3: Bu₃P⁺(C₁₆H₃₃)Br^- / toluene / 60 °C

4: hydrogenchloride; tin(ll) chloride / tetrahydrofuran

5: hydrazine hydrate / methanol

6: tetrahydrofuran

7: diisobutylaluminium hydride / dichloromethane

8: 1H-imidazole / dichloromethane

9: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

With 1H-imidazole; hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Bu₃P⁺(C₁₆H₃₃)Br^-; diisobutylaluminium hydride; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; tin(ll) chloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(97)00328-4

Reference yield:

: 20587-30-8
5-methyl-2-nitro-benzoic acid methyl ester

: 195717-72-7
{(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C

2: Bu₃P⁺(C₁₆H₃₃)Br^- / toluene / 60 °C

3: hydrogenchloride; tin(ll) chloride / tetrahydrofuran

4: hydrazine hydrate / methanol

5: tetrahydrofuran

6: diisobutylaluminium hydride / dichloromethane

7: 1H-imidazole / dichloromethane

8: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

With 1H-imidazole; hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Bu₃P⁺(C₁₆H₃₃)Br^-; diisobutylaluminium hydride; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; tin(ll) chloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(97)00328-4

Reference yield:

: 88071-91-4
5-bromomethyl-2-nitrobenzoic acid methyl ester

: 195717-72-7
{(R)-1-[4-(tert-Butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-2-naphthalen-2-yl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Bu₃P⁺(C₁₆H₃₃)Br^- / toluene / 60 °C

2: hydrogenchloride; tin(ll) chloride / tetrahydrofuran

3: hydrazine hydrate / methanol

4: tetrahydrofuran

5: diisobutylaluminium hydride / dichloromethane

6: 1H-imidazole / dichloromethane

7: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

With 1H-imidazole; hydrogenchloride; Bu₃P⁺(C₁₆H₃₃)Br^-; diisobutylaluminium hydride; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(97)00328-4