2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

Base Information

Chemical Name:2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester
CAS No.:131132-34-8
Molecular Formula:C₃₆H₅₉N₅O₈SSi₂
Molecular Weight:778.13
Hs Code.:

2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

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Chemical Property of 2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

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Technology Process of 2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

There total 4 articles about 2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131132-30-4
N³-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyl disiloxane-1,3-diyl)5-methyluridine

: 131132-34-8
2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / diethyl azodicarboxylate, triphenyl phosphorazidate, triphenylphosphine / tetrahydrofuran / 4 h / Ambient temperature

2: 94 percent / concd. NH₄OH / methanol / 1.5 h / Ambient temperature

3: tetrabutylammonium bromide, 0.2 M aq. NaHCO₃ / CH₂Cl₂ / 6.5 h / Ambient temperature

With ammonium hydroxide; diphenylphosphoranyl azide; tetrabutylammomium bromide; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00107a018

Reference yield:

: 131132-31-5
N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

: 131132-34-8
2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / concd. NH₄OH / methanol / 1.5 h / Ambient temperature

2: tetrabutylammonium bromide, 0.2 M aq. NaHCO₃ / CH₂Cl₂ / 6.5 h / Ambient temperature

With ammonium hydroxide; tetrabutylammomium bromide; sodium hydrogencarbonate; In methanol; dichloromethane;
DOI:10.1021/jm00107a018

Reference yield:

: 130983-87-8
1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H_.3H)-dione

: 131132-34-8
2,4,6-Triisopropyl-benzenesulfonic acid 1-((2R,3S,3aS,9aR)-3-azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: 70 percent / diethyl azodicarboxylate, triphenyl phosphorazidate, triphenylphosphine / tetrahydrofuran / 4 h / Ambient temperature

3: 94 percent / concd. NH₄OH / methanol / 1.5 h / Ambient temperature

4: tetrabutylammonium bromide, 0.2 M aq. NaHCO₃ / CH₂Cl₂ / 6.5 h / Ambient temperature

With ammonium hydroxide; diphenylphosphoranyl azide; tetrabutylammomium bromide; sodium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00107a018