N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine

Base Information

• Chemical Name: N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine
• CAS No.: 86671-00-3
• Molecular Formula: C₂₂H₂₁ClN₄O₂S₂
• Molecular Weight: 473.019
• Mol file: 86671-00-3.mol

Synonyms:

Chemical Property of N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine

There total 4 articles about N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide (3968-03-4) → N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine (86671-00-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) NaOMe / 1) methanol, reflux, 2) DMF, 120 deg C

2: H₂ / 8percent Pd-C / dioxane / Ambient temperature

3: H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

4: 2) Et₃N / 1) isopropanol, reflux, 1 h, 2) reflux, 2 h

With hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; water;

DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

N-(2-bromoethyl)-4'-chloro-2'-nitro-p-toluenesulfonanilide (86661-97-4) → N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine (86671-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 8percent Pd-C / dioxane / Ambient temperature

2: H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

3: 2) Et₃N / 1) isopropanol, reflux, 1 h, 2) reflux, 2 h

With hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; water;

DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

N-(2-Bromo-ethyl)-N-(4-chloro-2-isothiocyanato-phenyl)-4-methyl-benzenesulfonamide (345936-77-8) + phenylhydrazine (100-63-0) → N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine (86671-00-3)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1) isopropanol, reflux, 1 h, 2) reflux, 2 h;

DOI:10.1016/S0040-4020(01)91886-1

upstream raw materials:

N-(2-Bromo-ethyl)-N-(4-chloro-2-isothiocyanato-phenyl)-4-methyl-benzenesulfonamide

phenylhydrazine

N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide

N-(2-Amino-4-chloro-phenyl)-N-(2-bromo-ethyl)-4-methyl-benzenesulfonamide