4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone

Base Information

• Chemical Name: 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone
• CAS No.: 116693-10-8
• Molecular Formula: C₁₈H₁₆Cl₆N₂O₆
• Molecular Weight: 569.053
• Mol file: 116693-10-8.mol

Synonyms:

Chemical Property of 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone

There total 3 articles about 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-hydroxy-4-phenacyl-1,2,3,4-tetrahydropyrimidine (109853-26-1) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone (116693-10-8)

Guidance literature:

In pyridine; for 15h; Ambient temperature;

DOI:10.1039/P19880000725

Reference yield:

2-hydroxy-4-phenacyl-1,2,3,4-tetrahydropyrimidine (109853-26-1) → 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone (116693-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; ethyl acetate / 19 h / Ambient temperature

2: 1.) trifluoroacetic acid (TFA); 2.) 5percent aq. NaHCO₃ / 1.) CDCl₃; 2.) CDCl₃

With sodium hydrogencarbonate; trifluoroacetic acid; In pyridine; ethyl acetate;

DOI:10.1039/P19880000725

Reference yield:

8,9-bis-(2,2,2-trichloroethoxycarbonyl)-3-phenyl-2-oxa-8,9-diazabicyclo<3.3.1>nona-3,6-diene (109853-28-3) → 4-(2,2,2-trichloroethoxycarbonylamino)-2-but-3-enyl phenyl ketone (116693-10-8)

Guidance literature:

With sodium hydrogencarbonate; trifluoroacetic acid; Yield given. Multistep reaction; 1.) CDCl₃; 2.) CDCl₃;

DOI:10.1039/P19880000725

upstream raw materials:

8,9-bis-(2,2,2-trichloroethoxycarbonyl)-3-phenyl-2-oxa-8,9-diazabicyclo<3.3.1>nona-3,6-diene

2-hydroxy-4-phenacyl-1,2,3,4-tetrahydropyrimidine

2,2,2-Trichloroethyl chloroformate