6-(2-Hydroxyanilino)pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 6-(2-Hydroxyanilino)pyrimidine-2,4(1H,3H)-dione
• CAS No.: 105147-86-2
• Molecular Formula: C10H9N3O3
• Molecular Weight: 219.2
• DSSTox Substance ID: DTXSID90562405
• Wikidata: Q82446545
• Mol file: 105147-86-2.mol

Synonyms:105147-86-2;6-((2-Hydroxyphenyl)amino)pyrimidine-2,4(1H,3H)-dione;6-(2-Hydroxyanilino)pyrimidine-2,4(1H,3H)-dione;DTXSID90562405

Chemical Property of 6-(2-Hydroxyanilino)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

• XLogP3: 0.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 219.06439116
• Heavy Atom Count: 16
• Complexity: 340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NC2=CC(=O)NC(=O)N2)O

Technology Process of 6-(2-Hydroxyanilino)pyrimidine-2,4(1H,3H)-dione

There total 1 articles about 6-(2-Hydroxyanilino)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-chlorouracil (4270-27-3) + 2-amino-phenol (95-55-6) → 6-(2-hydroxyanilino)-1H-pyrimidine-2,4-dione (105147-86-2)

Guidance literature:

In sulfolane; at 110 ℃; for 1.5h;

DOI:10.1021/ja00195a055

Reference yield: 79.0%

4-chloro-2-fluorobenzaldehyde (61072-56-8) + 6-(2-hydroxyanilino)-1H-pyrimidine-2,4-dione (105147-86-2) → 8-chloro-10-(2-hydroxyphenyl)pyrimido[4,5-b]quinoline-2,4-dione (1448807-67-7)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; Microwave irradiation;

DOI:10.1021/jm400568p

Reference yield: 54.0%

6-(2-hydroxyanilino)-1H-pyrimidine-2,4-dione (105147-86-2) + 2-chloro-benzaldehyde (89-98-5) → 10-(2'-hydroxy)phenyl-5-deazaisoalloxazine (105147-87-3)

Guidance literature:

In N,N-dimethyl-formamide; at 160 - 180 ℃; for 5h;

DOI:10.1021/ja00195a055

upstream raw materials:

6-chlorouracil

2-amino-phenol

Downstream raw materials:

10-(2'-hydroxy)phenyl-5-deazaisoalloxazine

10-(2-Hydroxyphenyl)isoalloxazine

10-(2-Acetoxyphenyl)isoalloxazine

10-<2-(Butyloxy)phenyl>-3-butyl-5-deazaisoalloxazine