3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide

Base Information

Chemical Name:3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide
CAS No.:103660-93-1
Molecular Formula:C₁₅H₂₃NO₂S₂
Molecular Weight:313.485
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide

Chemical Property:

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Technology Process of 3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide

There total 2 articles about 3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1517-82-4
(-)-(S)-menthyl toluene-p-sulphinate

: 103660-93-1
3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -78 up to -40 deg C; 2.) THF, hexane, -78 deg C, 15 min

2: 1.) t-Bu-MgBr / 1.) THF, Et₂O, -90 deg C, 30 min; 2.) THF, Et₂O, -90 deg C, 60 min

With tert-butylmagnesium bromide; lithium diisopropyl amide;
DOI:10.1016/S0040-4020(01)96733-X

Reference yield:

: 103660-91-9
(+)-(R)-p-tolyl sulphinyl-N,N-dimethylthioacetamide

: 78-84-2
isobutyraldehyde

: 103660-93-1
3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide

Guidance literature:: With tert-butylmagnesium bromide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, Et₂O, -90 deg C, 30 min; 2.) THF, Et₂O, -90 deg C, 60 min;
DOI:10.1016/S0040-4020(01)96733-X

Reference yield:

: 103660-93-1
3-Hydroxy-4-methyl-2-((R)-toluene-4-sulfinyl)-pentanethioic acid dimethylamide

: 103660-97-5
(S)-3-Hydroxy-4-methyl-pentanethioic acid dimethylamide

: 103660-97-5,200562-76-1
(R)-3-hydroxy-N,N,4-trimethylpentanethioamide

Guidance literature:: With sodium dihydrogenphosphate; sodium amalgam; In methanol; at -20 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)96733-X