N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid

Base Information

• Chemical Name: N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid
• CAS No.: 116913-09-8
• Molecular Formula: C₃₀H₃₈N₄O₁₁S
• Molecular Weight: 662.718
• Mol file: 116913-09-8.mol

Synonyms:

Chemical Property of N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid

There total 5 articles about N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-methionyl-L-glutamic acid (14517-44-3) → N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid (116913-09-8)

Guidance literature:

With triethylamine; N-benzyloxycarbonyl-L-seryl=>L-tyrosyl=>L-methionyl=>L-glutamic acid; anschliessend Behandeln mit N-<N-Benzyloxycarbonyl-L-seryl>-L-tyrosylazid in Aether;

DOI:10.1557/JMR.2002.0386

Reference yield:

L-methionine (63-68-3,26062-47-5,58576-49-1) → N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid (116913-09-8)

Guidance literature:

Multi-step reaction with 5 steps

1: chlorocarbonic acid benzyl ester; aqueous NaHCO₃

2: chlorocarbonic acid ethyl ester; tributylamine; dioxane / anschliessend Behandeln mit L-Glutaminsaeure-diaethylester

3: aqueous methanol. NaOH

4: sodium; liquid NH₃

5: aqueous triethylamine / anschliessend Behandeln mit N-<N-Benzyloxycarbonyl-L-seryl>-L-tyrosylazid in Aether

With 1,4-dioxane; sodium hydroxide; tributyl-amine; ammonia; sodium; chloroformic acid ethyl ester; sodium hydrogencarbonate; benzyl chloroformate; triethylamine;

DOI:10.1557/JMR.2002.0386

Reference yield:

Cbz-Met-OH (1152-62-1) → N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid (116913-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: chlorocarbonic acid ethyl ester; tributylamine; dioxane / anschliessend Behandeln mit L-Glutaminsaeure-diaethylester

2: aqueous methanol. NaOH

3: sodium; liquid NH₃

4: aqueous triethylamine / anschliessend Behandeln mit N-<N-Benzyloxycarbonyl-L-seryl>-L-tyrosylazid in Aether

With 1,4-dioxane; sodium hydroxide; tributyl-amine; ammonia; sodium; chloroformic acid ethyl ester; triethylamine;

DOI:10.1557/JMR.2002.0386

upstream raw materials:

L-methionyl-L-glutamic acid

L-methionine

Cbz-Met-OH

(2S)-2-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-(methylsulfanyl)butanoyl]amino}pentanedioic acid