139272-66-5

Basic information

• Product Name: Aceclofenac Methyl Ester
• Synonyms: Aceclofenac Methyl Ester;2-[(2,6-Dichlorophenyl)aMino]benzeneacetic Acid 2-Methoxy-2-oxoethyl Ester;2-Methoxy-2-oxoethyl 2-(2-(2,6-dichlorophenylaMino)phenyl)acetate;Aceclofenac IMpurity-D(EP/BP);Aceclofenac EP IMpurity D;Methyl [[[2-[(2,6-dichlorophenyl)amino]phenyl] acetyl]oxy]acetate
• CAS NO: 139272-66-5
• Molecular Formula: C₁₇H₁₅Cl₂NO₄
• Molecular Weight: 368.2113
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 139272-66-5.mol

Chemical Properties

• Melting Point: 108-109°C
• Boiling Point: 448.373 °C at 760 mmHg
• Flash Point: 224.968 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Refrigerator
• CAS DataBase Reference: Aceclofenac Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Aceclofenac Methyl Ester(139272-66-5)
• EPA Substance Registry System: Aceclofenac Methyl Ester(139272-66-5)

Safety Data

• Hazardous Substances Data: 139272-66-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C17H15Cl2NO4/c1-23-16(22)10-24-15(21)9-11-5-2-3-8-14(11)20-17-12(18)6-4-7-13(17)19/h2-8,20H,9-10H2,1H3

Upstream product

• 67-56-1 methanol 
• 89796-99-6 aceclofenac 

Downstream Products

• 1262801-24-0 [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate 

Relevant articles and documents

Preparation method of carboxylic ester compound

The invention relates to a preparation method of a carboxylic ester compound, which comprises the following steps: reacting carboxylic acid with methanol in air under the catalysis of nitrite to obtain an ester compound, the preparation method disclosed by the invention has the advantages of rich raw material sources, cheap and easily available catalyst, mild reaction conditions, simplicity and convenience in operation and the like, a series of fatty carboxylic acids can be modified with high yield, and particularly, the traditional esterification method is generally not suitable for esterification of drug molecules. By utilizing the method, a series of known drug molecules can be modified, so that a shortcut is provided for discovering new drug molecules.

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.

Synthesis and evaluation of anti-inflammatory and analgesic activity of 3-[(5-substituted-1,3,4-oxadiazol-2-yl-thio)acetyl]-2H-chromen-2-ones

A novel series of 3-[(5-substituted-1,3,4-oxadiazol- 2-yl-thio)acetyl]-2H- chromen-2-one (7a-i) were synthesized by the condensation between the appropriately substituted 5-substituted-1,3,4-oxadiazolyl-2-thione (4a-i) derived from various existing NSAIDs and 3-(2-bromoacetyl)- 2H-chromen-2-one (6) under reflux in the presence of sodium ethoxide. Structure of the synthesized compounds was established on the basis of physicochemical, elemental analysis, and spectral data. The title compounds were screened for in vivo acute anti-inflammatory and analgesic activities at a dose of 200 mg/kg bw. Among the series, four compounds 7c, 7e, 7f, and 7h were found to possess a significant anti-inflammatory and analgesic activity profile. In addition, these compounds were also found to possess a less degree of ulcerogenic potential as compared to standard NSAIDs. Springer Science+Business Media, LLC 2010.