Aceclofenac Methyl Ester

Base Information

• Chemical Name: Aceclofenac Methyl Ester
• CAS No.: 139272-66-5
• Molecular Formula: C17H15Cl2NO4
• Molecular Weight: 368.216
• Mol file: 139272-66-5.mol

Synonyms:(2-Methoxy-2-oxo-ethyl) 2-[2-(2,6-dichloroanilino)phenyl]acetate;

Chemical Property of Aceclofenac Methyl Ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 108-109°C
• Refractive Index: 1.604
• Boiling Point: 448.373 °C at 760 mmHg
• Flash Point: 224.968 °C
• PSA: 64.63000
• Density: 1.37 g/cm³
• LogP: 4.06870
• Storage Temp.: Refrigerator

Purity/Quality:

98%Min ^*data from raw suppliers

AceclofenacMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Aceclofenac Methyl Ester

There total 1 articles about Aceclofenac Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methanol (67-56-1) + aceclofenac (89796-99-6) → 2-methoxy-2-oxoethyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate (139272-66-5)

Guidance literature:

With tert.-butylnitrite; at 40 ℃; for 48h;

Reference yield:

2-methoxy-2-oxoethyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate (139272-66-5) → [5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate (1262801-24-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / Reflux

2.1: potassium hydroxide / methanol / 12 h / Reflux

3.1: sodium ethanolate / ethanol / 4 h / Reflux

3.2: Reflux

With hydrazine hydrate; sodium ethanolate; potassium hydroxide; In methanol; ethanol;

DOI:10.1007/s00044-010-9494-z

upstream raw materials:

methanol

aceclofenac

Downstream raw materials:

[5-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylthio)-1,3,4-oxadiazol-2-yl]methyl [2-{(2,6-dichlorophenyl)amino}phenyl]acetate