2-Benzoyl-succinic acid diethyl ester

Base Information

• Chemical Name: 2-Benzoyl-succinic acid diethyl ester
• CAS No.: 10539-50-1
• Molecular Formula: C15H18O5
• Molecular Weight: 278.305
• DSSTox Substance ID: DTXSID70435027
• Nikkaji Number: J1.937.266I
• Mol file: 10539-50-1.mol

Synonyms:2-Benzoyl-succinic acid diethyl ester;10539-50-1;SCHEMBL4666968;DTXSID70435027;QNMQQXJHWZWNSI-UHFFFAOYSA-N;2-Benzoylsuccinic acid diethyl ester

Chemical Property of 2-Benzoyl-succinic acid diethyl ester

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 278.11542367
• Heavy Atom Count: 20
• Complexity: 344

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)CC(C(=O)C1=CC=CC=C1)C(=O)OCC

Technology Process of 2-Benzoyl-succinic acid diethyl ester

There total 12 articles about 2-Benzoyl-succinic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + ethyl bromoacetate (105-36-2) → diethyl 2-benzoylsuccinate (10539-50-1)

Guidance literature:

With sodium ethanolate; In ethanol; cooling;

DOI:10.1016/j.tetasy.2008.08.011

Reference yield: 94.0%

Benzoylformic acid (611-73-4) + but-2-enedioic acid diethyl ester (1520-50-9) → diethyl 2-benzoylsuccinate (10539-50-1)

Guidance literature:

With dipotassium hydrogenphosphate; Ir[2-(2,4-difluorophenyl)-5-trifluoromethylpyridine]₂(1,10-phenantroline)PF₆; In dichloromethane; water; at 20 ℃; for 9h; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.5b02392

Reference yield: 84.0%

diethyl 3-phenyl-3-trimethylsiloxy-1,2-cyclopropanedicarboxylate (92975-30-9) → diethyl 2-benzoylsuccinate (10539-50-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 12h; Ambient temperature;

upstream raw materials:

benzaldehyde

Diethyl maleate

ethanol

sodium 3-ethoxy-3-oxo-1-phenylprop-1-en-1-olate

Downstream raw materials:

diethylitaconate

5-oxo-1-o-tolyl-4-((Z)-o-tolylhydrazono)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

Succinimide

ethanol

Refernces

• 1、 Patrick. "-". . . Retrieved 1963.
• 2、 -. "A pigment derivative and dispersion of a color filter and a method of manufacturing composite pigment derivative, and its manufacturing method for a resin composition for a color filter, a color filter, and, an organic light emitting display device and a ". Paragraph 0253; 0254. . Retrieved 2017/03/21.
• 3、 Erbas, Secil Celik,Alp, Serap. "Synthesis and spectroscopic studies of N,N'-dialkyl derivatives of antisymmetrical 2h,5h-dihydropyrrolo[3,4-c]pyrrole-1,4-diones". . p. 329 - 335. Retrieved 2014/05/06.