Technology Process of 2,5-bis-benzyloxy-N-((R)-1-isopropylpiperidin-3-ylmethyl)nicotinamide
There total 9 articles about 2,5-bis-benzyloxy-N-((R)-1-isopropylpiperidin-3-ylmethyl)nicotinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 3 steps
1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / 1,1-dichloroethane / 0.17 h
2.1: triethylamine / 1,1-dichloroethane / 1 h
3.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.08 h
3.2: 2 h / 80 °C
With
1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydride; triethylamine;
In
1-methyl-pyrrolidin-2-one; 1,1-dichloroethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 67 h / 20 °C / Reflux
2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
3.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h / 20 °C
4.1: hydrazine hydrate / ethanol / 3 h / Reflux
5.1: triethylamine / 1,1-dichloroethane / 1 h
6.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.08 h
6.2: 2 h / 80 °C
With
sodium tris(acetoxy)borohydride; sodium hydride; hydrazine hydrate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,1-dichloroethane; ethanol; dichloromethane; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dichloromethane / 6 h / 0 - 20 °C
2.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2.2: pH ~ 12
3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18.5 h / 0 - 20 °C
4.1: hydrazine hydrate / ethanol / 3 h / Reflux
5.1: triethylamine / 1,1-dichloroethane / 1 h
6.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.08 h
6.2: 2 h / 80 °C
With
sodium tris(acetoxy)borohydride; sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,1-dichloroethane; ethanol; dichloromethane; mineral oil;