QUINAZOLINE-4-CARBONITRILE

Base Information

• Chemical Name: QUINAZOLINE-4-CARBONITRILE
• CAS No.: 36082-71-0
• Molecular Formula: C9H5 N3
• Molecular Weight: 155.159
• Hs Code.: 2933990090
• Mol file: 36082-71-0.mol

Synonyms:4-Cyanoquinazoline

Chemical Property of QUINAZOLINE-4-CARBONITRILE

Chemical Property:

• Vapor Pressure: 0.000131mmHg at 25°C
• Boiling Point: 334.1°C at 760 mmHg
• Flash Point: 118.1°C
• PSA: 49.57000
• Density: 1.29g/cm³
• LogP: 1.50148

Purity/Quality:

97% ^*data from raw suppliers

4-Quinazolinecarbonitrile >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of QUINAZOLINE-4-CARBONITRILE

There total 16 articles about QUINAZOLINE-4-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-(4-Chloro-phenyl)-2-phenyl-1-quinazolin-4-yl-ethanol (187336-13-6) → quinazoline-4-carbonitrile (36082-71-0) + quinazoline-4-carbonamide (16499-37-9) + 4-benzyl-quinazoline (92437-11-1) + 4'-chloro-2-phenylacetophenone (1889-71-0)

Guidance literature:

With potassium cyanide; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

DOI:10.1248/cpb.46.199

Reference yield: 60.0%

Benzoic acid cyano-phenyl-quinazolin-4-yl-methyl ester (99933-48-9) → quinazoline-4-carbonitrile (36082-71-0) + benzoic acid (65-85-0,8013-63-6) + phenyl(quinazolin-4-yl)methanone (55276-35-2)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; for 0.5h; Ambient temperature;

Reference yield: 35.0%

potassium cyanide (151-50-8) + 4-(α-benzyl-α-hydroxybenzyl)quinazoline (187336-04-5) → phenyl benzyl ketone (451-40-1) + quinazoline (253-82-7) + quinazoline-4-carbonitrile (36082-71-0)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 1h;

DOI:10.1248/cpb.46.199

upstream raw materials:

3-benzoyl-3,4-dihydro-4-quinazolinecarbonitrile

potassium cyanide

(4-Nitro-phenyl)-quinazolin-4-yl-methanone

benzaldehyde