4-benzylpiperazine-1-carboximidamide

Base Information

• Chemical Name: 4-benzylpiperazine-1-carboximidamide
• CAS No.: 105735-38-4
• Molecular Formula: C₁₂H₁₈N₄
• Molecular Weight: 218.302
• Mol file: 105735-38-4.mol

Synonyms:

Chemical Property of 4-benzylpiperazine-1-carboximidamide

Chemical Property:

• Vapor Pressure: 0.000142mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzylpiperazine-1-carboximidamide

There total 4 articles about 4-benzylpiperazine-1-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-phenylmethylpiperazine (2759-28-6) + S-Methylisothiourea sulfate (867-44-7,147895-43-0) → 4-benzylpiperazine-1-carboximidamide (7773-69-5,105735-38-4)

Guidance literature:

1-phenylmethylpiperazine; S-Methylisothiourea sulfate; In water; for 2h; Reflux;

With barium(II) chloride; In water; for 1.5h; Reflux;

DOI:10.1007/s11426-011-4477-6

Reference yield:

4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine (400785-59-3) → 4-benzylpiperazine-1-carboximidamide (7773-69-5,105735-38-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/S0040-4039(02)01390-4

Reference yield:

1-phenylmethylpiperazine (2759-28-6) → 4-benzylpiperazine-1-carboximidamide (7773-69-5,105735-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: polymer-supported carbodiimide / CH₂Cl₂ / 16 h / 20 °C

1.2: 87 percent / tris(2-aminoethyl)amine, polymer-bound / CH₂Cl₂ / 16 h / 20 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 6 h / 20 °C

With polymer-supported carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(02)01390-4

upstream raw materials:

4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine

1-phenylmethylpiperazine

S-Methylisothiourea sulfate

Downstream raw materials:

Methyl 2-(4-benzylpiperazin-1-yl)pyrimidine-5-carboxylate

1-benzyl-4-carbamimidoyl-1-methyl-piperazinium; iodide hydriodide

Refernces

• 1、 Guisado, Olga,Martínez, Sonia,Pastor, Joaquín. "A novel, facile methodology for the synthesis of N,N′-bis(tert-butoxycarbonyl)-protected guanidines using polymer-supported carbodiimide". . p. 7105 - 7109. Retrieved 2007/10/03.