N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester

Base Information

Chemical Name:N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester
CAS No.:103580-37-6
Molecular Formula:C₃₂H₃₉Cl₄N₅O₁₀S
Molecular Weight:827.567
Hs Code.:

N-<N'-<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-<N<sup>2</sup>-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester

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Chemical Property of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester

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Technology Process of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester

There total 6 articles about N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-4-[(4-Chloro-3-sulfamoyl-benzoyl)-hydrazono]-1-{(S)-2-[((S)-1-ethoxycarbonyl-3-phenyl-propyl)-(2,2,2-trichloro-ethoxycarbonyl)-amino]-propionyl}-pyrrolidine-2-carboxylic acid ethyl ester

: 103580-37-6,126373-58-8,126373-59-9
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester

Guidance literature:: With sodium cyanoborohydride; In ethanol; at 0 - 5 ℃; for 45h; Yield given;
DOI:10.1021/jm00168a013

Reference yield:

: 5378-62-1
3-sulfamoyl-4-chlorobenzoic acid hydrazide

: 103580-37-6,126373-58-8,126373-59-9
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 3 h / Ambient temperature

2: NaBH₃CN / ethanol / 45 h / 0 - 5 °C

With sodium cyanoborohydride; In ethanol;
DOI:10.1021/jm00168a013

Reference yield:

: 92893-50-0
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

: 103580-37-6,126373-58-8,126373-59-9
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 72 h / Ambient temperature

4: ethanol / 3 h / Ambient temperature

5: NaBH₃CN / ethanol / 45 h / 0 - 5 °C

With oxalyl dichloride; sodium cyanoborohydride; triethylamine; N,N-dimethyl-formamide; pyridinium chlorochromate; In ethanol; dichloromethane;
DOI:10.1021/jm00168a013