1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol

Base Information

• Chemical Name: 1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol
• CAS No.: 116650-94-3
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.291
• Mol file: 116650-94-3.mol

Synonyms:

Chemical Property of 1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol

There total 2 articles about 1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-methoxyphenylboronic acid (5720-07-0) + para-bromoacetophenone (99-90-1) → 1-(4'-methoxy-biphenyl-4-yl)-ethanone (13021-18-6) + 1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol (60992-53-2,116650-94-3)

Guidance literature:

With [{(pentamethylcyclopentadienylRh(2-phenylpyridnate)(μ-dppm)Pd(2-chlorophenyl thiosemicarbazone))}PF₆]; caesium carbonate; In ethanol; at 80 ℃; for 3h; Sealed tube;

DOI:10.1021/acs.organomet.0c00594

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) + 1-(4-fluorophenyl)ethanone (403-42-9) → 1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol (60992-53-2,116650-94-3) + 1-(4-Fluorophenyl)ethanol (403-41-8)

Guidance literature:

With C₁₄H₁₄Cl₄N₈Pd₂; potassium tert-butylate; isopropyl alcohol; at 80 ℃; for 20h;

DOI:10.1021/acscatal.6b01421

Reference yield: 80.0%

1-(4'-methoxy-[1,1'-biphenyl]-4-yl)ethanol (60992-53-2,116650-94-3) + 1,1'-carbonyldiimidazole (530-62-1) → 1-[1-(4'-methoxy-biphenyl-4-yl)-ethyl]-1H-imidazole

Guidance literature:

In tetrahydrofuran; at 80 - 90 ℃;

DOI:10.1016/S0968-0896(00)00076-6

upstream raw materials:

4-methoxyphenylboronic acid

1-(4-fluorophenyl)ethanone

para-bromoacetophenone