N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide
CAS No.:1254036-87-7
Molecular Formula:C₃₅H₃₂F₂N₆O₇S₂
Molecular Weight:750.804
Hs Code.:

N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Chemical Property of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Chemical Property:

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Technology Process of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

There total 14 articles about N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1254036-87-7,1364801-75-1
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 2.75 h / 0 - 10 °C / Inert atmosphere; Large scale

2: ethanol; iron / 20 - 25 °C / Large scale

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

4: pyridine / 2 h / 20 °C

5: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 3 h / 120 °C / Microwave irradiation

With pyridine; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); potassium acetate; iron; In 1,4-dioxane; methanol; water;

Reference yield:

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1254036-85-5,1364801-65-9
6-chloro-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

: 1254036-87-7,1364801-75-1
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: With potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); In 1,4-dioxane; water; at 120 ℃; for 3h; Microwave irradiation;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1254036-87-7,1364801-75-1
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzenesulfonyl chloride; sodium hydride / N,N-dimethyl-formamide / 0.33 h / 10 °C / Inert atmosphere

1.2: 10 - 20 °C

2.1: zinc(II) chloride; lithium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -10 °C / Inert atmosphere

2.2: 60 °C / Inert atmosphere

2.3: 0 - 5 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C

4.1: dichloromethane / 3 h / 20 °C

5.1: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 3 h / 120 °C / Microwave irradiation

With potassium phosphate; carbon tetrabromide; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); sodium hydride; benzenesulfonyl chloride; triphenylphosphine; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;