N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide
CAS No.:1254036-68-4
Molecular Formula:C₂₉H₂₈F₂N₆O₅S
Molecular Weight:610.641
Hs Code.:

N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Chemical Property of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Technology Process of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

There total 13 articles about N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1254036-68-4,1364798-61-7
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: methanol / 2.75 h / 0 - 10 °C / Inert atmosphere; Large scale

2: ethanol; iron / 20 - 25 °C / Large scale

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

4: pyridine / 2 h / 20 °C

5: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 3 h / 120 °C / Microwave irradiation

6: sodium hydroxide / water; isopropyl alcohol / 2 h / 20 °C

With pyridine; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); potassium acetate; iron; sodium hydroxide; In 1,4-dioxane; methanol; water; isopropyl alcohol;

Reference yield:

: 1254036-87-7,1364801-75-1
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

: 1254036-68-4,1364798-61-7
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: With sodium hydroxide; In water; isopropyl alcohol; at 20 ℃; for 2h;

Reference yield:

: 1254036-80-0
6-chloro-1-(phenylsulfonyl)-4-(trimethylstannanyl)-1H-indazole

: 1254036-68-4,1364798-61-7
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.05 h / 100 °C / Microwave irradiation

2: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / -25 - -20 °C

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C

4: dichloromethane / 3 h / 20 °C

5: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 3 h / 120 °C / Microwave irradiation

6: sodium hydroxide / water; isopropyl alcohol / 2 h / 20 °C

With potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); diisobutylaluminium hydride; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;